| Sulfamethoxazole-trimethoprim double-blind, placebo-controlled, crossover trial in Machado-Joseph disease: sulfamethoxazole-trimethoprim increases cerebrospinal fluid level of biopterin. | |
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MedLine Citation:
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PMID: 8748680 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed a double-blind, placebo-controlled, crossover trial of sulfamethoxazole-trimethoprim (S-T) in 8 patients with Machado-Joseph disease (MJD), and measured the blood and cerebrospinal fluid levels of biopterins, biogenic amines or metabolites, and folate. The clinical results were as follows; mild improvements of hyperreflexia of knee jerks and of rigospasticity of the legs during S-T treatment period. In addition, S-T significantly reduced the times of 8 motor activities on the timed tests. The biochemical results showed that basal levels of all biopterins and homovanillic acid in the cerebrospinal fluid (CSF) were reduced to less than half the levels of those of controls with other neurological diseases. After S-T treatment, total and oxidized form of biopterins in the CSF increased significantly. Therefore, S-T may be effective to neurologic deficits through its mechanism of increasing the level of brain biopterins. |
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Authors:
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T Sakai; T Matsuishi; S Yamada; H Komori; H Iwashita |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of neural transmission. General section Volume: 102 ISSN: 0300-9564 ISO Abbreviation: J. Neural Transm. Gen. Sect. Publication Date: 1995 |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9002201 Medline TA: J Neural Transm Gen Sect Country: AUSTRIA |
Other Details:
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Languages: eng Pagination: 159-72 Citation Subset: IM |
Affiliation:
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Department of Neurology, National Chikugo Hospital, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopterin / cerebrospinal fluid* Double-Blind Method Humans Machado-Joseph Disease / drug therapy* Male Middle Aged Time Factors Trimethoprim-Sulfamethoxazole Combination / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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22150-76-1/Biopterin; 8064-90-2/Trimethoprim-Sulfamethoxazole Combination |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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