Document Detail


Sulcal Span in Azheimer's Disease, Amnestic Mild Cognitive Impairment, and Healthy Controls.
MedLine Citation:
PMID:  22297645     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Differences of cortical morphology between healthy controls (HC), amnestic mild cognitive impairment (MCI), and Alzheimer's disease (AD) have been repeatedly investigated using voxel-based morphometry (VBM). However, the results obtained using mainly VBM remain difficult to interpret as they can be explained by various mechanisms. The aim of the present study was to evaluate the differences of cortical morphology between HC, MCI, and AD patients using a new post-processing method based on reconstruction and identification of cortical sulci. Thirty HC, 33 MCI, and 30 AD patients were randomly selected from the ADNI database. For each subject, cortical sulci were reconstructed and automatically identified using Brainvisa software. Depth and fold opening of nine large sulci were compared between HC, MCI, and AD patients. Fold opening of parietaloccipital fissure and intraparietal sulcus on both sides strongly differed between the 3 groups, with gradual increase from HC to MCI of about 1 mm and from MCI to AD of about 2 mm (right intraparietal: p = 0.005; left intraparietal: p = 0.004; right parietaloccipital: p = 0.003; left parietaloccipital: p = 0.0009). Results were left unchanged after adjustment for age, gender, and level of education. These variables were also strongly linked to neuropsychological scores, independent of age, gender, and level of education. In the present study, we found important regional differences of cortical morphology with gradual deterioration from HC to MCI to AD. The most important differences were found in parietaloccipital fissure and intraparietal sulcus. Further studies are needed to understand the involved underlying mechanisms.
Authors:
Peggy Reiner; Eric Jouvent; Edouard Duchesnay; Rémi Cuingnet; Jean-François Mangin; Hugues Chabriat
Related Documents :
22654825 - Comparative endocrinology of aging and longevity regulation.
22808195 - Ageing increases vulnerability to aβ42 toxicity in drosophila.
22762175 - Childhood obesity and skeletal-dental maturity.
25175175 - How can computerized interpretation algorithms adapt to gender/age differences in ecg m...
21578545 - Non-isovalent substitution in a zintl phase with the tinisi type structure, camg(1-x)ag...
8257175 - Use of hospital inpatient care in adolescence.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-1
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  -     ISSN:  1875-8908     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Univ Paris Diderot, Sorbonne Paris Cité, UMR 740 INSERM, Paris, France and AP-HP, Lariboisière Hosp, Department of Neurology, Paris, France LNAO, Neurospin, I2BM, CEA, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Value of Diagnostic tests to Predict Conversion to Alzheimer's Disease in Young and Old Patients wit...
Next Document:  Dysfunctional pro-ceramide, ER stress, and insulin/IGF signaling networks with progression of Alzhei...