Document Detail

Suicide and exposure to organophosphate insecticides: cause or effect?
MedLine Citation:
PMID:  15776467     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Suicide using pesticides as agent is recognized as a major cause of pesticide poisoning. METHODS: A literature review of mortality and morbidity studies related to suicide among pesticide-exposed populations, and of human and animal studies of central nervous system toxicity related to organophosphate (OP) pesticides was performed. RESULTS: Suicide rates are high in farming populations. Animal studies link OP exposure to serotonin disturbances in the central nervous system, which are implicated in depression and suicide in humans. Epidemiological studies conclude that acute and chronic OP exposure is associated with affective disorders. Case series and ecological studies also support a causal association between OP use and suicide. CONCLUSIONS: OPs are not only agents for suicide. They may be part of the causal pathway. Emphasizing OPs solely as agents for suicide shifts responsibility for prevention to the individual, reducing corporate responsibility and limiting policy options available for control.
L London; A J Flisher; C Wesseling; D Mergler; H Kromhout
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  47     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-23     Completed Date:  2005-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  308-21     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 Wiley-Liss, Inc.
Occupational and Environmental Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
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MeSH Terms
Agricultural Workers' Diseases / chemically induced*,  epidemiology,  prevention & control
Depressive Disorder / chemically induced*,  epidemiology
Insecticides / adverse effects*,  poisoning
Phosphoric Acid Esters / adverse effects*,  poisoning
Public Policy
Suicide / prevention & control,  statistics & numerical data*
World Health
Reg. No./Substance:
0/Insecticides; 0/Phosphoric Acid Esters

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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