Document Detail


Suicide by gabapentin overdose.
MedLine Citation:
PMID:  21554310     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gabapentin is an antiepileptic drug that is prescribed for both FDA-approved and multiple off-label conditions, and has a relatively safe side-effect profile. Rare cases of overdose-related adverse effects have been reported in the literature. Described herein are the circumstances and autopsy findings of a 62-year-old woman with a history of depression, whose death was caused by intentional ingestion of excess gabapentin. The postmortem peripheral blood gabapentin concentration as determined by high-performance liquid chromatography/tandem mass spectroscopy was 88 μg/mL. Previously reported cases of individuals surviving gabapentin overdoses are discussed and compared with this case. Based on a review of the available literature, this appears to be the first published report of a death due solely to gabapentin toxicity.
Authors:
Owen Middleton
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-05-06
Journal Detail:
Title:  Journal of forensic sciences     Volume:  56     ISSN:  1556-4029     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-02     Completed Date:  2012-04-05     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1373-5     Citation Subset:  IM    
Copyright Information:
© 2011 American Academy of Forensic Sciences.
Affiliation:
Hennepin County Medical Examiner's Office, 530 Chicago Avenue, Minneapolis, MN 55415, USA. owen.middleton@co.hennepin.mn.us
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MeSH Terms
Descriptor/Qualifier:
Amines / blood,  poisoning*
Anticonvulsants / blood,  poisoning*
Cyclohexanecarboxylic Acids / blood,  poisoning*
Depressive Disorder, Major / psychology
Drug Overdose
Female
Forensic Toxicology
Humans
Middle Aged
Suicide*
gamma-Aminobutyric Acid / blood,  poisoning*
Chemical
Reg. No./Substance:
0/Amines; 0/Anticonvulsants; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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