Document Detail

Suicide attempt by pure citalopram overdose causing long-lasting severe sinus bradycardia, hypotension and syncopes: successful therapy with a temporary pacemaker.
MedLine Citation:
PMID:  10958266     Owner:  NLM     Status:  MEDLINE    
In few cases, pure citalopram overdose at doses above 600 mg showed electro-cardiographic changes with prolonged QT intervals and sinus bradycardia gradually resolving within 12-24 hours after intoxication. We report on a 32-year-old patient with borderline personality disorder (BPD) who ingested a total of 800 mg citalopram to attempt suicide due to an interpersonal disappointment. She developed severe sinus bradycardia with a minimal pulse rate of 41/min within about 4 hours after intoxication lasting up to six days during intensive care unit (ICU) treatment. Further, hypotension and syncopes occurred. No QT interval prolongations were recorded. To our knowledge, this is the first case report of pure citalopram overdose-induced long-lasting sinus bradycardia associated with severe hypotension and intermittent syncopes that required therapy with a temporary pacemaker.
H B Rothenhäusler; C Hoberl; S Ehrentrout; H P Kapfhammer; M M Weber
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacopsychiatry     Volume:  33     ISSN:  0176-3679     ISO Abbreviation:  Pharmacopsychiatry     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-12-14     Completed Date:  2000-12-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8402938     Medline TA:  Pharmacopsychiatry     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  150-2     Citation Subset:  IM    
Department of Psychiatry, Ludwig-Maximilians-University of Munich, Germany.
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MeSH Terms
Borderline Personality Disorder / drug therapy*
Bradycardia / chemically induced*,  therapy
Citalopram / poisoning*
Hypotension / chemically induced*,  therapy
Interpersonal Relations
Pacemaker, Artificial*
Serotonin Uptake Inhibitors / poisoning*
Suicide, Attempted*
Syncope / chemically induced*
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 59729-33-8/Citalopram

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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