Document Detail

Suicidal behaviour in youths with depression treated with new-generation antidepressants: meta-analysis.
MedLine Citation:
PMID:  17077427     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Concern exists that antidepressants can cause suicidality in youths with depression. AIMS: To determine the pooled risk of self-harm and suicidal behaviour from randomised trials of newer antidepressants. METHOD: A meta-analysis was carried out to calculate odds ratios for the combined data. RESULTS: Self-harm or suicide-related events occurred in 71 of 1487 (4.8%) of depressed youths treated with antidepressants v. 38 of 1254 (3.0%) of those given placebo (fixed effects odds ratio 1.70, 95% CI 1.13-2.54, P=0.01). There was a trend for individual suicidal thoughts, attempts and self-harm to occur more often in youths taking antidepressants than in those given placebo, but none of these differences was statistically significant. CONCLUSIONS: Antidepressants may cause a small short-term risk of self-harm or suicidal events in children and adolescents with major depressive disorder.
Bernadka Dubicka; Sarah Hadley; Christopher Roberts
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  189     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-01     Completed Date:  2007-03-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  393-8     Citation Subset:  IM    
University Department of Child and Adolescent Psychiatry, Royal Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK.
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MeSH Terms
Antidepressive Agents / adverse effects*
Depressive Disorder / drug therapy*
Randomized Controlled Trials as Topic
Risk Factors
Self-Injurious Behavior / chemically induced*
Serotonin Uptake Inhibitors / adverse effects*
Suicide, Attempted / statistics & numerical data*
Reg. No./Substance:
0/Antidepressive Agents; 0/Serotonin Uptake Inhibitors
Comment In:
Evid Based Ment Health. 2007 Aug;10(3):89   [PMID:  17652571 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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