| Suggested Connections Between Risk Factors of Intracranial Aneurysms: A Review. | |
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MedLine Citation:
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PMID: 23242844 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this article is to review studies of aneurysm risk factors and the suggested hypotheses that connect the different risk factors and the underlying mechanisms governing the aneurysm natural history. The result of this work suggests that at the center of aneurysm evolution there is a cycle of wall degeneration and weakening in response to changing hemodynamic loading and biomechanic stress. This progressive wall degradation drives the geometrical evolution of the aneurysm until it stabilizes or ruptures. Risk factors such as location, genetics, smoking, co-morbidities, and hypertension seem to affect different components of this cycle. However, details of these interactions or their relative importance are still not clearly understood. |
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Authors:
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Juan R Cebral; Marcelo Raschi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-14 |
Journal Detail:
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Title: Annals of biomedical engineering Volume: - ISSN: 1521-6047 ISO Abbreviation: Ann Biomed Eng Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361512 Medline TA: Ann Biomed Eng Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center for Computational Fluid Dynamics, George Mason University, Fairfax, VA, USA, jcebral@gmu.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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