Document Detail


Suggested connections between risk factors of intracranial aneurysms: a review.
MedLine Citation:
PMID:  23242844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this article is to review studies of aneurysm risk factors and the suggested hypotheses that connect the different risk factors and the underlying mechanisms governing the aneurysm natural history. The result of this work suggests that at the center of aneurysm evolution there is a cycle of wall degeneration and weakening in response to changing hemodynamic loading and biomechanic stress. This progressive wall degradation drives the geometrical evolution of the aneurysm until it stabilizes or ruptures. Risk factors such as location, genetics, smoking, co-morbidities, and hypertension seem to affect different components of this cycle. However, details of these interactions or their relative importance are still not clearly understood.
Authors:
Juan R Cebral; Marcelo Raschi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-12-14
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  41     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-10     Completed Date:  2013-12-31     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1366-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology,  physiopathology
Cerebrovascular Circulation
Hemodynamics
Humans
Intracranial Aneurysm / etiology*,  pathology,  physiopathology
Risk Factors
Grant Support
ID/Acronym/Agency:
R01 NS059063/NS/NINDS NIH HHS; R01NS059063/NS/NINDS NIH HHS
Comments/Corrections

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