Document Detail

Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure.
MedLine Citation:
PMID:  21357284     Owner:  NLM     Status:  MEDLINE    
The obesity epidemic has focused attention on relationships of sugars and sugar-sweetened beverages (SSBs) to cardiovascular risk factors. Here we report cross-sectional associations of SSBs, diet beverages, and sugars with blood pressure (BP) for United Kingdom and US participants of the International Study of Macro/Micronutrients and Blood Pressure. Data collected include four 24-hour dietary recalls, two 24-hour urine collections, 8 BP readings, and questionnaire data for 2696 people ages 40 to 59 years of age from 10 US/United Kingdom population samples. Associations of SSBs, diet beverages, and sugars (fructose, glucose, and sucrose) with BP were assessed by multiple linear regression. SSB intake related directly to BP, with P values of 0.005 to <0.001 (systolic BP) and 0.14 to <0.001 (diastolic BP). SSB intake higher by 1 serving per day (355 mL/24 hours) was associated with systolic/diastolic BP differences of +1.6/+0.8 mm Hg (both P<0.001) and +1.1/+0.4 mm Hg (P<0.001/<0.05) with adjustment for weight and height. Diet beverage intake was inversely associated with BP (P 0.41 to 0.003). Fructose- and glucose-BP associations were direct, with significant sugar-sodium interactions: for individuals with above-median 24-hour urinary sodium excretion, fructose intake higher by 2 SD (5.6% kcal) was associated with systolic/diastolic BP differences of +3.4/+2.2 mm Hg (both P<0.001) and +2.5/+1.7 mm Hg (both P=0.002) with adjustment for weight and height. Observed independent, direct associations of SSB intake and BP are consistent with recent trial data. These findings, plus adverse nutrient intakes among SSB consumers, and greater sugar-BP differences for persons with higher sodium excretion lend support to recommendations that intake of SSBs, sugars, and salt be substantially reduced.
Ian J Brown; Jeremiah Stamler; Linda Van Horn; Claire E Robertson; Queenie Chan; Alan R Dyer; Chiang-Ching Huang; Beatriz L Rodriguez; Liancheng Zhao; Martha L Daviglus; Hirotsugu Ueshima; Paul Elliott;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-28
Journal Detail:
Title:  Hypertension     Volume:  57     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-17     Completed Date:  2011-07-04     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  695-701     Citation Subset:  IM    
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MeSH Terms
Beverages / adverse effects*
Blood Pressure / physiology*
Cross-Sectional Studies
Diet Surveys
Dietary Sucrose / adverse effects*
Fructose / adverse effects*
Glucose / adverse effects*
Hypertension / etiology*
Linear Models
Middle Aged
Sodium / urine
Sweetening Agents / adverse effects*
Grant Support
G0801056//Medical Research Council; R01 HL050490/HL/NHLBI NIH HHS; R01 HL050490-17/HL/NHLBI NIH HHS; R01-HL050490/HL/NHLBI NIH HHS; //Medical Research Council
Reg. No./Substance:
0/Dietary Sucrose; 0/Sweetening Agents; 30237-26-4/Fructose; 9NEZ333N27/Sodium; IY9XDZ35W2/Glucose
Comment In:
Hypertension. 2011 Apr;57(4):676-8   [PMID:  21357281 ]

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