Document Detail


Sugammadex in the management of rocuronium-induced anaphylaxis.
MedLine Citation:
PMID:  21149287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anaphylaxis during anaesthesia is a rare event that in ∼60-70% of cases is secondary to neuromuscular blocking agents. It has been suggested previously that the recent introduction of sugammadex may provide a novel therapeutic approach to the management of rocuronium-induced anaphylaxis. We describe the case of a 33-yr-old female who suffered a severe anaphylactic reaction to rocuronium, presenting with cardiovascular collapse on induction of anaesthesia. After 19 min of traditional management, she was given a bolus of sugammadex 500 mg. This was associated with an improvement in the adverse haemodynamic state. The underlying reasons for this are unclear, but sugammadex may potentially be a useful adjunct in the management of rocuronium-induced anaphylaxis.
Authors:
N J McDonnell; T J G Pavy; L K Green; P R Platt
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-12-10
Journal Detail:
Title:  British journal of anaesthesia     Volume:  106     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-14     Completed Date:  2011-02-16     Revised Date:  2011-08-30    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  199-201     Citation Subset:  IM    
Affiliation:
School of Women's and Infants' Health, University of Western Australia, Australia. nolan.mcdonnell@health.wa.gov.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Anaphylaxis / chemically induced,  drug therapy*,  physiopathology
Androstanols / adverse effects*
Female
Hemodynamics / drug effects
Humans
Neuromuscular Nondepolarizing Agents / adverse effects*
gamma-Cyclodextrins / therapeutic use*
Chemical
Reg. No./Substance:
0/Androstanols; 0/Neuromuscular Nondepolarizing Agents; 0/Sugammadex; 0/gamma-Cyclodextrins; 143558-00-3/rocuronium
Comments/Corrections
Comment In:
Br J Anaesth. 2011 Aug;107(2):275-6   [PMID:  21757555 ]
Br J Anaesth. 2011 Jun;106(6):911-2   [PMID:  21576105 ]

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