Document Detail


Sufentanil in anaesthesiology and intensive therapy.
MedLine Citation:
PMID:  23801512     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sufentanil, a potent α-1 agonistic opioid, was synthesized in mid-1970s. It was introduced into clinical practice ten years later, gaining some popularity over the last twenty years. A piperidine derivative, sufentanil has been reported to be 6-10 times more potent than fentanyl, depending on the route of administration; it has been registered for intravenous, epidural and subarachnoid administration. Its reported off-label use has included intra-articular and intranasal administration; moreover, it has been applied as an adjunct in peripheral blocks. In the review, contemporary uses of sufentanil, together with detailed pharmacokinetics and pharmacodynamics are presented. The author concludes that the limited side effects of sufentanil, together with its attractive pharmacokinetic profile, should promote its wider use in clinical practice.
Authors:
Dariusz Maciejewski
Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Anaesthesiology intensive therapy     Volume:  44     ISSN:  1731-2515     ISO Abbreviation:  Anaesthesiol Intensive Ther     Publication Date:    2012 Jan-Mar
Date Detail:
Created Date:  2013-06-26     Completed Date:  2014-02-10     Revised Date:  2014-07-14    
Medline Journal Info:
Nlm Unique ID:  101472620     Medline TA:  Anaesthesiol Intensive Ther     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / adverse effects,  pharmacology,  therapeutic use*
Anesthetics, Intravenous / adverse effects,  pharmacology,  therapeutic use*
Fentanyl / administration & dosage,  therapeutic use
Humans
Intensive Care / methods
Off-Label Use
Sufentanil / adverse effects,  pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Intravenous; AFE2YW0IIZ/Sufentanil; UF599785JZ/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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