| Sudomotor dysfunction in patients with optic neuritis. | |
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MedLine Citation:
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PMID: 20213266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Optic neuritis (ON) is a frequent initial manifestation of multiple sclerosis (MS). Autonomic failure affecting the pupillary function is known to exist in ON patients, and patients with MS are known to have more widespread autonomic dysfunction. For example, sudomotor dysfunction is well known in MS. We carried out a study investigating sudomotor abnormalities in ON patients, and later followed these patients at risk of developing MS. METHODS: Firstly, sudomotor function was measured by sympathetic skin responses (SSRs) in 13 ON patients and in 22 healthy controls. Secondly, thermoregulatory sweating was measured by an evaporimeter after a heating stimulus in 13 ON patients and in 14 healthy control subjects. RESULTS: The SSR latencies to electrical stimuli in the ON patients were significantly prolonged in the upper and lower extremities (p = 0.013-0.002), indicating sudomotor dysfunction. No statistically significant thermoregulatory sweating dysfunction could be found in the ON patients compared to the controls. All ON patients underwent a follow-up (mean duration 12.5 years) during which eight ON patients (62%) converted to clinically definite MS. It seemed that SSRs had no value for identifying patients who later developed MS. INTERPRETATION: Our results enlarge the knowledge of autonomic disorders in ON patients, showing that sudomotor function may also be involved. |
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Authors:
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Anne Saari; Uolevi Tolonen; Eija Pääkkö; Kalervo Suominen; Jukka Jauhiainen; Kyösti A Sotaniemi; Vilho V Myllylä |
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Publication Detail:
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Type: Journal Article Date: 2010-03-07 |
Journal Detail:
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Title: Clinical autonomic research : official journal of the Clinical Autonomic Research Society Volume: 20 ISSN: 1619-1560 ISO Abbreviation: Clin. Auton. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-08-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106549 Medline TA: Clin Auton Res Country: Germany |
Other Details:
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Languages: eng Pagination: 199-204 Citation Subset: IM |
Affiliation:
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Department of Neurology, Oulu University Hospital, Oulu, Finland. anne.saari@ppshp.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Adult Autonomic Nervous System Diseases / pathology, physiopathology* Body Temperature Regulation / physiology* Brain / pathology Electric Stimulation Female Follow-Up Studies Galvanic Skin Response / physiology* Humans Magnetic Resonance Imaging Male Multiple Sclerosis / pathology, physiopathology* Optic Neuritis / pathology, physiopathology* Risk Spinal Cord Diseases / pathology Sweating / physiology* Sympathetic Nervous System / physiopathology Water Loss, Insensible / physiology Young Adult |
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