| Sudomotor dysfunction in autoimmune autonomic ganglionopathy: a follow-up study. | |
| | |
MedLine Citation:
|
PMID: 22127477 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: We have previously shown that sudomotor dysfunction in autoimmune autonomic ganglionopathy is severe, widespread, and predominantly post-ganglionic. However, the long-term changes in sudomotor function have not been studied in detail. Our objective was to characterize the long-term changes in sudomotor dysfunction in patients with autoimmune autonomic ganglionopathy. METHODS: Changes in sudomotor function were compared in a cohort of nine α3 nAChR antibody positive autoimmune autonomic ganglionopathy patients over an approximate 5-year period. Standard measurements of sudomotor function were used including the thermoregulatory sweat test and quantitative sudomotor axon reflex test. RESULTS: Total body anhidrosis on thermoregulatory sweat testing showed improvement in four of nine patients. Quantitative sudomotor axon reflex testing for both forearm and foot sites was variable with four of nine patients showing improvement in total sweat output. Distribution of sudomotor dysfunction at follow-up was post-ganglionic in seven of nine patients at the foot site and three of nine patients at the forearm site. Overall, sudomotor dysfunction was post-ganglionic in seven of nine patients throughout the follow-up period (62.4 ± 19.4 months). INTERPRETATION: Sudomotor dysfunction in autoimmune autonomic ganglionopathy was severe and widespread throughout the follow-up period for the majority of patients studied. Sudomotor dysfunction was predominantly post-ganglionic throughout the follow-up period. |
| | |
Authors:
|
Kurt Kimpinski; Valeria Iodice; Paola Sandroni; Robert D Fealey; Steven Vernino; Phillip A Low |
Related Documents
:
|
22472317 - Acute kidney injury in dengue fever using acute kidney injury network criteria: inciden... 17095017 - Serum bdnf levels and weight gain in schizophrenic patients on long-term treatment with... 11431237 - Structural brain abnormalities in chronic schizophrenia at the extremes of the outcome ... 20636287 - Abnormal mechanisms of antisaccade generation in schizophrenia patients and unaffected ... 10990387 - Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric h... 950097 - Effects of anticopper therapy on hepatocellular mitochondria in patients with wilson's ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-30 |
Journal Detail:
|
Title: Clinical autonomic research : official journal of the Clinical Autonomic Research Society Volume: - ISSN: 1619-1560 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9106549 Medline TA: Clin Auton Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Clinical Neurological Sciences, University Hospital, London Health Sciences Centre, University of Western Ontario, London, ON, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: (99m)Tc-labeled Rituximab for Imaging B Lymphocyte Infiltration in Inflammatory Autoimmune Disease P...
Next Document: Investigation of the correlation between stoichiometry and thermoelectric properties in a PtSb(2) si...