| Sudden unexplained infant death in 20 regions in Europe: case control study. | |
| | |
MedLine Citation:
|
PMID: 14738790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: After striking changes in rates of sudden unexplained infant death (SIDS) around 1990, four large case-control studies were set up to re-examine the epidemiology of this syndrome. The European Concerted Action on SIDS (ECAS) investigation was planned to bring together data from these and new studies to give an overview of risk factors for the syndrome in Europe. METHODS: We undertook case-control studies in 20 regions. Data for more than 60 variables were extracted from anonymised records of 745 SIDS cases and 2411 live controls. Logistic regression was used to calculate odds ratios (ORs) for every factor in isolation, and to construct multivariate models. FINDINGS: Principal risk factors were largely independent. Multivariately significant ORs showed little evidence of intercentre heterogeneity apart from four outliers, which were eliminated. Highly significant risks were associated with prone sleeping (OR 13.1 [95% CI 8.51-20.2]) and with turning from the side to the prone position (45.4 [23.4-87.9]). About 48% of cases were attributable to sleeping in the side or prone position. If the mother smoked, significant risks were associated with bed-sharing, especially during the first weeks of life (at 2 weeks 27.0 [13.3-54.9]). This OR was partly attributable to mother's consumption of alcohol. Mother's alcohol consumption was significant only when baby bed-shared all night (OR increased by 1.66 [1.16-2.38] per drink). For mothers who did not smoke during pregnancy, OR for bed-sharing was very small (at 2 weeks 2.4 [1.2-4.6]) and only significant during the first 8 weeks of life. About 16% of cases were attributable to bed-sharing and roughly 36% to the baby sleeping in a separate room. INTERPRETATION: Avoidable risk factors such as those associated with inappropriate infants' sleeping position, type of bedding used, and sleeping arrangements strongly suggest a basis for further substantial reductions in SIDS incidence rates. |
| | |
Authors:
|
R G Carpenter; L M Irgens; P S Blair; P D England; P Fleming; J Huber; G Jorch; P Schreuder |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Lancet Volume: 363 ISSN: 1474-547X ISO Abbreviation: Lancet Publication Date: 2004 Jan |
Date Detail:
|
Created Date: 2004-01-23 Completed Date: 2004-03-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
|
Languages: eng Pagination: 185-91 Citation Subset: AIM; IM |
Affiliation:
|
Medical Statistics Unit, Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. bob.carpenter@lshtm.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcohol Drinking
/
epidemiology Case-Control Studies Child of Impaired Parents / statistics & numerical data Cross-Cultural Comparison Europe / epidemiology Female Humans Incidence Infant Infant, Newborn Logistic Models Male Odds Ratio Prone Position / physiology Risk Factors Sleep / physiology Smoking / epidemiology Sudden Infant Death / diagnosis, epidemiology*, prevention & control |
| Comments/Corrections | |
Comment In:
|
Lancet. 2004 May 8;363(9420):1558
[PMID:
15135621
]
Lancet. 2004 Mar 20;363(9413):994 [PMID: 15043979 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification of Bartonella strains isolated from wild and domestic ruminants by a single-step PCR ...
Next Document: Effect of methylprednisolone when added to standard treatment with intravenous immunoglobulin for Gu...