Document Detail


Sudden unexpected neonatal death in the first week of life: autopsy findings from a specialist centre.
MedLine Citation:
PMID:  19529996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Sudden unexpected early neonatal death (SUEND) in the first week of life shares features with sudden unexpected death in infancy (SUDI) but is not included as SUDI, which is limited to post-perinatal deaths. The aim of this study was to review SUEND autopsies performed in a single specialist centre over a 10-year period, (1996-2005). METHODS: Retrospective analysis of >1500 consecutively performed paediatric autopsies performed by paediatric pathologists at one centre conducted according to a standard protocol including ancillary investigations. SUENDs were identified and autopsy findings reviewed. RESULTS: Of 1516 post-mortem examinations, 180 were first-week neonatal deaths, 55 (31%) presenting as SUEND. Thirty-two (58%) were explained following autopsy, whilst the remainder were unexplained; most deaths during sleep were associated with adult co-sleeping. Around 40% of explained deaths were associated with undiagnosed congenital abnormalities, mainly congenital heart disease. In addition, there were nine infection-related deaths and three deaths from unsuspected metabolic disease (fatty acid oxidation defects). CONCLUSION: There are distinct differences between SUEND and SUDI, with significantly more explained deaths in the former and a much greater proportion due to congenital abnormalities and metabolic disease.
Authors:
Martin A Weber; Michael T Ashworth; R Anthony Risdon; Ivan Brooke; Marian Malone; Neil J Sebire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  22     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-08-25     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  398-404     Citation Subset:  IM    
Affiliation:
Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Autopsy
Cause of Death
Humans
Infant, Newborn
Retrospective Studies
Specialization
Sudden Infant Death / epidemiology,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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