Document Detail

Sudden unexpected death of a term fetus in an anticardiolipin-positive mother.
MedLine Citation:
PMID:  15017471     Owner:  NLM     Status:  MEDLINE    
A term male fetus suddenly and unexpectedly died in utero at the 40th week of gestation. The mother had a regular and unremarkable pregnancy except for an anticardiolipin antibodies positivity. The histological examination of the cardiac conduction system showed islands of conduction tissue in the central fibrous body, known as persistent fetal dispersion. The brainstem examination revealed a severe bilateral hypoplasia of the arcuate nucleus. This morphological finding has been described in more than 35% of our stillborn as well as sudden infant death syndrome (SIDS) cases, independently from the presence of anticardiolipin antibodies. Some authors have given emphasis to the possible lethal association of maternal autoantibodies and QT prolongation. Our findings emphasize the need of an accurate postmortem examination including the study of brainstem and cardiac conduction system in every case of unexpected late intrauterine death, following the same standardized autopsy protocol adopted in SIDS cases.
Giulia Ottaviani; Anna M Lavezzi; Lino Rossi; Luigi Matturri
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of perinatology     Volume:  21     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-03-12     Completed Date:  2004-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Institute of Pathology, University of Milan, Italy.
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MeSH Terms
Antibodies, Anticardiolipin / blood*
Diagnosis, Differential
Fetal Death*
Heart Conduction System / pathology*
Pregnancy Complications / blood,  pathology*
Pregnancy Trimester, Third
Reg. No./Substance:
0/Antibodies, Anticardiolipin

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