Document Detail

Sudden unexpected death in children with heart disease.
MedLine Citation:
PMID:  18377551     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review a mortality database, and identify all sudden unexpected deaths in patients followed by the cardiac program. DESIGN: Retrospective review of prospectively maintained database. RESULTS: Over 8 years, we identified 80 sudden unexpected deaths, among which there were sufficient data in 69 (24 females). Patients died at a median age of 17.2 months (28 days-18.8 years). Forty-six patients had 2 functional ventricles and 23 had received palliation for a single-functional ventricle. Patients with a single ventricle died at a younger age (median 120 days; 28 days-17.2 years) and sooner after last assessment (median 27 days; 1-146 days) than patients in the biventricular group (median age 2 years; 43 days-18.8 years; median time since last assessment 49 days, 1 days-1 year) (P < .01; P = .01). Thrombosis was the most common cause (61%) of death in the single-ventricle group. Arrhythmia or presumed arrhythmia was the most common cause (46%) of death in the biventricular group. Fifty-one patients had undergone surgery. Six patients had primary electrophysiological disease, and 5 had cardiomyopathy. Eight deaths occurred in patients with pulmonary vascular disease. CONCLUSION: Our study demonstrates that sudden unexpected death occurred at a frequency of at least 10 patients per year over an 8-year period with 55,730 patient encounters. We were able to determine a clinical cause of death in most patients. Arrhythmias (30%) and pulmonary vascular disease (13%) are important causes of sudden death. Simple aortic valve disease and hypertrophic cardiomyopathy are rare (4%) causes of sudden death in childhood. Infants and young children with surgical shunts comprise 23% of sudden unexpected deaths that occur within a month of the last evaluation. Close surveillance of these patients is warranted.
Shubhayan Sanatani; Gregory Wilson; Charles R Smith; Robert M Hamilton; William G Williams; Ian Adatia
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Congenital heart disease     Volume:  1     ISSN:  1747-0803     ISO Abbreviation:  -     Publication Date:  2006 May 
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-97     Citation Subset:  IM    
Children's Heart Center, British Columbia's Children's Hospital, Vancouver, BC, Canada.
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MeSH Terms
Age Factors
Cause of Death
Child, Preschool
Death, Sudden / epidemiology*
Heart Diseases / mortality*
Ontario / epidemiology
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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