| Sudden unexpected death in children with heart disease. | |
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MedLine Citation:
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PMID: 18377551 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review a mortality database, and identify all sudden unexpected deaths in patients followed by the cardiac program. DESIGN: Retrospective review of prospectively maintained database. RESULTS: Over 8 years, we identified 80 sudden unexpected deaths, among which there were sufficient data in 69 (24 females). Patients died at a median age of 17.2 months (28 days-18.8 years). Forty-six patients had 2 functional ventricles and 23 had received palliation for a single-functional ventricle. Patients with a single ventricle died at a younger age (median 120 days; 28 days-17.2 years) and sooner after last assessment (median 27 days; 1-146 days) than patients in the biventricular group (median age 2 years; 43 days-18.8 years; median time since last assessment 49 days, 1 days-1 year) (P < .01; P = .01). Thrombosis was the most common cause (61%) of death in the single-ventricle group. Arrhythmia or presumed arrhythmia was the most common cause (46%) of death in the biventricular group. Fifty-one patients had undergone surgery. Six patients had primary electrophysiological disease, and 5 had cardiomyopathy. Eight deaths occurred in patients with pulmonary vascular disease. CONCLUSION: Our study demonstrates that sudden unexpected death occurred at a frequency of at least 10 patients per year over an 8-year period with 55,730 patient encounters. We were able to determine a clinical cause of death in most patients. Arrhythmias (30%) and pulmonary vascular disease (13%) are important causes of sudden death. Simple aortic valve disease and hypertrophic cardiomyopathy are rare (4%) causes of sudden death in childhood. Infants and young children with surgical shunts comprise 23% of sudden unexpected deaths that occur within a month of the last evaluation. Close surveillance of these patients is warranted. |
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Authors:
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Shubhayan Sanatani; Gregory Wilson; Charles R Smith; Robert M Hamilton; William G Williams; Ian Adatia |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Congenital heart disease Volume: 1 ISSN: 1747-0803 ISO Abbreviation: - Publication Date: 2006 May |
Date Detail:
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Created Date: 2008-04-01 Completed Date: 2008-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256510 Medline TA: Congenit Heart Dis Country: United States |
Other Details:
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Languages: eng Pagination: 89-97 Citation Subset: IM |
Affiliation:
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Children's Heart Center, British Columbia's Children's Hospital, Vancouver, BC, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age Factors Cause of Death Child Child, Preschool Death, Sudden / epidemiology* Female Heart Diseases / mortality* Humans Infant Male Ontario / epidemiology Retrospective Studies Risk Factors |
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