Document Detail

Sudden unexpected death due to a previously undiagnosed plasma cell dyscrasia.
MedLine Citation:
PMID:  18665886     Owner:  NLM     Status:  MEDLINE    
The plasma cell dyscrasias are a diverse group of disorders characterized by the production of a clonal paraprotein. Sudden death is a recognized complication of the plasma cell dyscrasias, most commonly in individuals with cardiac involvement by amyloidosis. However, the current forensic literature has no reported cases in which sudden death resulted from complications of a plasma cell dyscrasia that was first diagnosed by postmortem histologic examination. We present the case of a woman whose sudden and unexpected death resulted from a seizure. Postmortem examination revealed no evidence of trauma or a grossly identifiable natural disease process that would have accounted for her death. However, microscopic and immunohistologic studies revealed a previously undiagnosed plasma cell dyscrasia, the clonality of which was determined by immunohistochemical studies for immunoglobulin light chains, that was not associated with amyloid deposition. This case elucidates a previously unrecognized cause of sudden unexpected death and illustrates the importance of microscopic studies in selected cases examined in medical examiner/coroner offices.
Rebecca A Hamilton; Barbara C Wolf
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-07-26
Journal Detail:
Title:  Journal of forensic sciences     Volume:  53     ISSN:  1556-4029     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-21     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1194-7     Citation Subset:  IM    
Office of the District 21 Medical Examiner, Fort Myers, FL 33907, USA.
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MeSH Terms
Bone Marrow Diseases / pathology
Death, Sudden / etiology*
Forensic Pathology
Immunoglobulin Light Chains / analysis
Immunoglobulin lambda-Chains / analysis
Middle Aged
Paraproteinemias / diagnosis*
Plasma Cells / pathology
Pulmonary Embolism / pathology
Seizures / etiology
Reg. No./Substance:
0/Immunoglobulin Light Chains; 0/Immunoglobulin lambda-Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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