Document Detail


Sudden sensorineural hearing loss: A vascular cause? Analysis of prothrombotic risk factors in head and neck.
MedLine Citation:
PMID:  22928918     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: This aim of this study was to determine the prevalence of thrombophilic risk factors in sudden sensorineural hearing loss, central retinal vein occlusion, and stroke associated with small vessel disease, with the purpose of investigating and reinforcing the vascular hypothesis in the pathogenesis of sudden sensorineural hearing loss. Design: Case-control study. Genetic and acquired risk factors of these three groups were compared with healthy controls. Study sample: Forty-nine, 60, and 101 patients affected respectively by sudden sensorineural hearing loss, central retinal vein occlusion, or stroke associated with small vessel disease, enrolled during a three-year period were compared with 210 healthy controls. Results: The frequency of hyperhomocysteinemia (homocysteine ≥ 15 μmol/L) was higher in each disease group than in controls. A statically significant, albeit weak, correlation between the MTHFR C677T mutation and hyperhomocysteinemia was found in all three diseases. Conclusions: Hyperhomocysteinemia proved to be a risk factor for sudden sensorineural hearing loss. Based on these results, we propose to analyse homocysteine in sudden sensorineural hearing loss patients and, if its values are high, to evaluate the presence of MTHFR C677T mutation.
Authors:
Fusconi Massimo; Chistolini Antonio; de Virgilio Armando; Greco Antonio; Massaro Fulvio; Turchetta Rosaria; Benincasa Anna Teresa; Tombolini Mario; de Vincentiis Marco
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-29
Journal Detail:
Title:  International journal of audiology     Volume:  -     ISSN:  1708-8186     ISO Abbreviation:  Int J Audiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140017     Medline TA:  Int J Audiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
* Department of Sensory Organs, 'Sapienza' University of Rome , Italy.
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