| Sudden neurologic death after intrathecal methotrexate. | |
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MedLine Citation:
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PMID: 2304423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methotrexate leukoencephalopathy is a chronic syndrome of ataxia and confusion which may progress to seizures, coma, and death. We report a fatal case of this syndrome in a patient who displayed no evidence of the typical prodrome of neurologic symptoms or signs. This patient suffered brain death after receiving 11 doses of intrathecal methotrexate for leukemic meningitis. Since leukoencephalopathy was not clinically suspected, this case underscores the need for a test that would reliably monitor central nervous system toxicity due to intrathecal therapy. |
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Authors:
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T Shore; M J Barnett; G L Phillips |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Medical and pediatric oncology Volume: 18 ISSN: 0098-1532 ISO Abbreviation: Med. Pediatr. Oncol. Publication Date: 1990 |
Date Detail:
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Created Date: 1990-03-23 Completed Date: 1990-03-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7506654 Medline TA: Med Pediatr Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 159-61 Citation Subset: IM |
Affiliation:
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Leukemia and Bone Marrow Transplant Program of British Columbia, Vancouver General Hospital, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Death* Brain Edema / chemically induced Death, Sudden / etiology* Humans Injections, Spinal Leukemia-Lymphoma, Adult T-Cell / drug therapy Leukoencephalopathy, Progressive Multifocal / chemically induced Male Meningeal Neoplasms / drug therapy Methotrexate / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
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59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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