| Sudden infant death syndrome: a testable hypothesis and mechanism. | |
| | |
MedLine Citation:
|
PMID: 536116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Sudden Infant Death Syndrome (SIDS) is the most frequent cause of death in infants aged between one month and one year, yet its cause remains unknown. The present hypothesis is that most infants who die of SIDS have an abnormality of the catecholaminergic system, possible genetically determined, which results in a decreased thermogenic response to cold, owing to a deficiency in noradrenaline (NA), which eventually results in severe hypothermia. A series of complex, but interrelated reactions of the infant to the hypothermia and its consequences leads to death. The final mechanism of regulatory failure involves a deterioration of cardiorespiratory function resulting from hypoxia, metabolic acidosis and hypoglycemia. The etiology of "near miss" for SIDS is also unknown. It is postulated that these infants have a similar but milder deficiency which may be due, in part, to genetic factors. Determinations of central and peripheral catecholamines in "near miss" and normal infants will be performed to test this hypothesis. |
| | |
Authors:
|
A C Cornwell |
Related Documents
:
|
10443486 - Sudden infant death syndrome: what questions should we ask? 2320496 - Preventing the sudden infant death syndrome. 7756806 - Is the higher postneonatal mortality in lower social status groups due to sids? 15173546 - Air pollution and sudden infant death syndrome. 10048606 - Neurodevelopmental outcome at 1 year in zimbabwean neonates with extreme hyperbilirubin... 778366 - A controlled study of intrathecal antibiotic therapy in gram-negative enteric meningiti... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The International journal of neuroscience Volume: 10 ISSN: 0020-7454 ISO Abbreviation: Int. J. Neurosci. Publication Date: 1979 |
Date Detail:
|
Created Date: 1980-05-14 Completed Date: 1980-05-14 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 31-44 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acidosis
/
complications Anoxia / complications Apnea / complications Body Temperature Regulation Cold Temperature / adverse effects Heart Arrest / etiology Humans Hypoglycemia / complications Hypothermia / complications Infant Lung / blood supply Models, Biological Norepinephrine / deficiency Receptors, Adrenergic / physiology Respiratory Insufficiency / etiology Sudden Infant Death / etiology* Vasoconstriction |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Adrenergic; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Degeneration of interneurons in the lateral geniculate nucleus after 5,6-dihydroxytryptamine treatme...
Next Document: The relationships between conceptual and semantic-lexical disorders in aphasia.