Document Detail

Sudden infant death syndrome and lipoproteins.
MedLine Citation:
PMID:  2666828     Owner:  NLM     Status:  MEDLINE    
Lipoprotein secretion and vitamin E transport depend on an adequate supply of inositol which functions synergistically with choline. Feeding rats a choline deficient diet was associated with decreased linoleic and arachidonic acids and increased docosapentenoic and docosahexenoic acids in liver phosphatidylethanolamine. Lipoprotein secretion by the liver is impaired by long chain omega 3 fatty acids and by the high carbohydrate diet of Kwashiorkor. Pulmonary surfactant is a lipoprotein which functions in preventing alveolar collapse in the lung. Inositol supplements to premature infants altered the composition of surfactant phospholipids and reduced the need for oxygen therapy. Oxygen free radicals, generated in oxygen therapy, convert low density lipoproteins (LDL) into potent toxins, without adequate antioxidants and free radical scavengers to block free radical generation. Vitamin E deficiency predisposes humans to increased susceptability to oxygen toxicity leading to Bronchopulmonary dysplasia (BPD), a form of chronic pulmonary insufficiency.
G M Reid
Related Documents :
591268 - Treatment of oral estramustine phosphate (estracyt) in prostatic carcinoma: influences ...
10903478 - The capacity of various non-esterified fatty acids to suppress lipid transfer inhibitor...
1535648 - Low density lipoprotein from humans supplemented with n-3 fatty acids depresses both ld...
15182938 - Activation and inhibition of candida rugosa and bacillus-related lipases by saturated f...
19757408 - Implication of agathic acid from utah juniper bark as an abortifacient compound in cattle.
24706628 - Dynamics of fatty-acid composition of neutral acylglycerols in maturing euonymus fruits.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  29     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-08-31     Completed Date:  1989-08-31     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Free Radicals
Infant, Newborn
Lipoproteins / metabolism*
Liver / metabolism
Models, Biological
Oxygen / metabolism
Selenium / deficiency
Sudden Infant Death / etiology*,  metabolism
Vitamin E Deficiency / complications
Reg. No./Substance:
0/Free Radicals; 0/Lipoproteins; 7782-44-7/Oxygen; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inherited collagen disorders.
Next Document:  Prolactin, human nutrition and evolution, and the relation to cystic fibrosis.