| Sudden death and sickle cell trait: medicolegal considerations and implications. | |
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MedLine Citation:
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PMID: 19465821 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sickle cell trait, which affects approximately 8% of American blacks, is generally felt to be a benign condition. Exercise-related collapse in persons with sickle cell trait is a rare but serious complication. It occurs most often in military recruits and deconditioned athletes undergoing intense physical training, but can also occur in other situations in which an individual exerts himself beyond his limits of endurance. Local hypoxia causes intravascular sickling, in turn causing vascular occlusion and organ and tissue damage. This can result in rhabdomyolysis, myocardial ischemia, arrhythmias and sudden death. Risk factors include poor physical conditioning, inadequate hydration, excess heat and/or altitude, heat-retaining clothing and febrile illness. Seven cases are presented, and the implications of the diagnosis of sickle trait-associated collapse and sudden death are discussed. |
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Authors:
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Lisa Scheinin; Charles V Wetli |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The American journal of forensic medicine and pathology Volume: 30 ISSN: 1533-404X ISO Abbreviation: Am J Forensic Med Pathol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-09-29 Revised Date: 2011-02-02 |
Medline Journal Info:
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Nlm Unique ID: 8108948 Medline TA: Am J Forensic Med Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 204-8 Citation Subset: IM |
Affiliation:
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Los Angeles Department of Coroner, University of Southern California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Death, Sudden / etiology* Forensic Pathology Humans Male Middle Aged Organ Size Physical Exertion / physiology* Rhabdomyolysis / physiopathology Sickle Cell Trait / physiopathology* Spleen / pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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