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Sudden death in the first two years of life following immunization in the Republic of Korea.
MedLine Citation:
PMID:  22783912     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background:  Because the peak age for incidence of sudden deaths in infancy temporally coincides with the age of infant primary immunization, some have raised the question whether immunization is a risk factor for sudden death in infancy. Recent occurrence of two sudden deaths in infants in Korea renewed concerns about causal association between immunization and sudden deaths in infants. Methods:  Retrospective review of data from Korea Centers for Disease Control and Prevention adverse events following immunization surveillance system and vaccine compensation programs. Results:  From 1994 to 2011, a total of 45 cases of sudden deaths in the first two years of life following immunization were reported in Korea. The causes of death were classified as follows: infectious diseases (n=13); accidental injuries (n=7); congenital abnormalities (n=2); and malignancy (n=1). Of 20 sudden deaths in infancy, nine deaths met Brighton Collaboration case definition level I and II, therefore were classified as possible sudden infant death syndrome cases. Hepatitis B vaccine (n=13) was the most frequent vaccine with temporal association with sudden deaths in the first two years of life. Conclusion:  Few sudden deaths in the first two years of life following immunization have been reported, despite the use of universal immunization in Korea. Majority of deaths in infancy did not meet case definition for sudden infant death syndrome. Encouraging investigators to perform thorough investigation including postmortem autopsy and death scene examination may promote data comparability and provide guidance on decision making in vaccine safety monitoring and response system in Korea. © 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Authors:
Young June Choe; Jong-Hee Kim; Hyun Jin Son; Geun-Ryang Bae; Duk-Hyoung Lee
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-11
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.
Affiliation:
Division of Vaccine Preventable Disease Control and National Immunization Program, Korea Centers for Disease Control and Prevention, Seoul, Korea.
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