| Sudden death and Wegener's granulomatosis of the pituitary. | |
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MedLine Citation:
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PMID: 11028850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Involvement of brain parenchyma or meninges in ANCA-associated small-vessel vasculitis such as Wegener's granulomatosis (WG) is not uncommon. In contrast, involvement of the pituitary is exceedingly rare with only a few cases reported so far. The diagnosis is usually made on the basis of imaging techniques and abnormal pituitary function tests in the setting of active systemic vasculitis. However, histology-proven involvement of the pituitary by WG has not been reported so far. We report a case of WG with histology-proven granulomatous necrotizing inflammation of the pituitary and hypothalamo-pituitary stalk, disclosed at autopsy after the patient had died suddenly and unexpectedly in his sleep. In a setting of histology-proven WG, these findings were regarded as a pituitary manifestation of the disorder. A distinct cause of death could not be found, hence we speculate that hypothalamo-pituitary inflammation due to WG may have caused the sudden death in this patient. |
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Authors:
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A Woywodt; H Knoblauch; R Kettritz; W Schneider; U Göbel |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Scandinavian journal of rheumatology Volume: 29 ISSN: 0300-9742 ISO Abbreviation: Scand. J. Rheumatol. Publication Date: 2000 |
Date Detail:
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Created Date: 2000-10-25 Completed Date: 2000-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0321213 Medline TA: Scand J Rheumatol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 264-6 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Franz-Volhard-Clinic, Humboldt-University, Berlin, Germany. woywodt@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Death, Sudden* Humans Immunoglobulins, Intravenous / therapeutic use Magnetic Resonance Imaging Male Pituitary Diseases / diagnosis*, pathology Pituitary Gland, Anterior / pathology* Vasopressins / therapeutic use Wegener Granulomatosis / diagnosis*, drug therapy, pathology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous; 11000-17-2/Vasopressins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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