Document Detail

Sudden cardiac death: epidemiology, causes, and mechanisms.
MedLine Citation:
PMID:  3621277     Owner:  NLM     Status:  MEDLINE    
In the United States, more than 300,000 sudden cardiac deaths (SCD) occur each year, the most common underlying etiology of which is coronary heart disease (CHD). With increasing age, the proportion of cardiovascular causes among all natural sudden deaths increases, and the fraction of CHD deaths that are sudden decreases. The lower incidence of coronary atherosclerosis in women is reflected in their proportionately lower risk of SCD. There are no data suggesting specific hereditary factors in risk for SCD due to CHD. On an individual basis, the known risk factors for CHD cannot distinguish those at risk for SCD from those at risk for other manifestations of CHD. Pathologic studies of SCD victims have shown that extensive coronary atherosclerosis is a major marker; healed myocardial infarction is a common finding, as is myocardial hypertrophy. Nonatherosclerotic coronary artery abnormalities may be associated with SCD. Chronic congestive heart failure is a common cause of SCD. Other etiologies include inflammatory, infiltrative, neoplastic and degenerative processes, diseases of the cardiac valves, and primary electrophysiologic abnormalities. The largest group of prehospital cardiac arrest victims have ventricular fibrillation identified on initial contact, with their survival outcome being intermediate between patients with ventricular tachycardia (best outcome) and those with bradyarrhythmia or asystole (worst outcome) on initial contact.
R J Myerburg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiology     Volume:  74 Suppl 2     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  2-9     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Coronary Disease / complications*,  pathology
Death, Sudden / etiology*
Heart Arrest / complications*,  physiopathology,  therapy
Middle Aged
Terminology as Topic
Grant Support

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