Document Detail


Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment.
MedLine Citation:
PMID:  15235919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The case concerns the sudden death of a 29-year-old male during clozapine therapy started 2 weeks before. He had a history of treatment-resistant chronic schizophrenia. A complete immunohistochemical study was performed on heart specimens. Histologically, the heart presented diffuse eosinophilic infiltrates located around perivascular structures and focal myocyte necrosis with numerous interstitial eosinophils admixed with histiocytes. The diagnosis of acute myocarditis with an eosinophilic infiltrate was established as the cause of death. The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.
Authors:
Vittorio Fineschi; Margherita Neri; Irene Riezzo; Emanuela Turillazzi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of legal medicine     Volume:  118     ISSN:  0937-9827     ISO Abbreviation:  Int. J. Legal Med.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2005-01-27     Completed Date:  2005-02-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9101456     Medline TA:  Int J Legal Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  307-9     Citation Subset:  IM    
Affiliation:
Institute of Legal Medicine, University of Foggia Ospedali Riuniti, Foggia, Italy. vfinesc@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipsychotic Agents / adverse effects*,  therapeutic use
Clozapine / adverse effects*,  therapeutic use
Death, Sudden, Cardiac / etiology*
Fatal Outcome
Humans
Hypersensitivity, Delayed / etiology*
Male
Myocarditis / chemically induced*,  diagnosis,  immunology
Schizophrenia / drug therapy
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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