Document Detail

Sudden cardiac death associated with hypoplasia of the coronary arteries and conduction system alteration.
MedLine Citation:
PMID:  9185940     Owner:  NLM     Status:  MEDLINE    
We present a case of sudden cardiac death in a 24-year-old woman with evidence of hypoplasia of the left anterior descending (LAD) and posterior descending (PDA) coronary arteries. These vessels averaged 0.7 mm in internal diameter combined, in contrast to an average of 2.4 mm in control coronary arteries (p < 0.001). The myocardium exhibited areas of acute and chronic ischemic change. Also, the cardiac conduction system (CCS) had diffuse cellular enlargement, believed to be secondary to ischemia. The cells of the sinoatrial node (SAN) and the Purkinje cells of the proximal right bundle branch (RBB) averaged 28.5 and 25.6 microns, respectively. These were significantly larger than the SAN cells (21.6 microns, p = 0.002) and larger than the Purkinje cells (15.9 microns, p = 0.012) of control cases. We report that hypoplastic coronary artery disease is a cause of sudden death, is associated with varying degrees of ischemic change in the heart, and can be associated with condition system alteration.
E T Smith; G J Davis
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of forensic medicine and pathology     Volume:  18     ISSN:  0195-7910     ISO Abbreviation:  Am J Forensic Med Pathol     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-30     Completed Date:  1997-07-30     Revised Date:  2011-02-02    
Medline Journal Info:
Nlm Unique ID:  8108948     Medline TA:  Am J Forensic Med Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
Department of Pathology, Bowman Gray School of Medicine, North Carolina Baptist Hospital, Winston-Salem, USA.
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MeSH Terms
Coronary Vessel Anomalies / pathology*
Coronary Vessels / pathology
Death, Sudden, Cardiac / etiology*,  pathology
Fatal Outcome
Heart Conduction System / abnormalities*,  pathology
Heart Diseases / pathology*
Myocardial Ischemia / pathology*
Sinoatrial Node / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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