Document Detail

Sudden bilateral sensorineural hearing loss as the presenting symptom of meningeal carcinomatosis of gastric cancer: report of a case.
MedLine Citation:
PMID:  20496139     Owner:  NLM     Status:  MEDLINE    
Meningeal carcinomatosis is the diffuse infiltration of the meninges by metastatic carcinoma. A 62-year-old man presented with a sudden onset of profound hearing loss affecting both ears. Brain magnetic resonance imaging showed increased signal intensity on T1-weighted images of both vestibulocochlear nerves. Upper gastrointestinal endoscopy revealed a large type 3 gastric cancer, and the pathological diagnosis was poorly differentiated adenocarcinoma. Although combination chemotherapy with oral S-1 and weekly paclitaxel and radiation therapy were performed, the patient's condition gradually worsened, and he eventually died 12 weeks after the onset of deafness. Isolated bilateral hearing loss is therefore considered to be a rare first manifestation of meningeal carcinomatosis.
Tetsuro Ohno; Yozo Yokoyama; Ryuusuke Aihara; Erito Mochiki; Takayuki Asao; Hiroyuki Kuwano
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-23
Journal Detail:
Title:  Surgery today     Volume:  40     ISSN:  1436-2813     ISO Abbreviation:  Surg. Today     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2011-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  561-5     Citation Subset:  IM    
Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, 371-8511, Japan.
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MeSH Terms
Adenocarcinoma / secondary*
Fatal Outcome
Hearing Loss, Bilateral / etiology*
Hearing Loss, Sensorineural / etiology*
Hearing Loss, Sudden / etiology*
Magnetic Resonance Imaging
Meningeal Carcinomatosis / secondary*
Middle Aged
Stomach Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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