Document Detail


Sudden Unexpected Death in Infancy: Biological Mechanisms.
MedLine Citation:
PMID:  25301029     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Sudden unexpected death in infancy (SUDI) covers both explained and unexplained deaths. Unexplained cases or SIDS are likely to have multiple neural mechanisms contributing to the final event. The evidence ranges from subtle physiological signs related to autonomic control, to findings at autopsy of altered neurotransmitter systems, including the serotonergic system, a network that has an extensive homeostatic role in cardio-respiratory and thermoregulatory control. Processes may be altered by the vulnerability of the infant due to age, poor motor ability, or a genetic predisposition. The fatal event may occur in response to an environmental stress. A single final physiological route to death seems unlikely. An understanding of the reasons for explained SUDI also reminds us that a thorough investigation is required after each death occurs.
Authors:
Barbara C Galland; Dawn E Elder
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Publication Detail:
Type:  REVIEW     Date:  2014-9-19
Journal Detail:
Title:  Paediatric respiratory reviews     Volume:  -     ISSN:  1526-0550     ISO Abbreviation:  Paediatr Respir Rev     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-10-10     Completed Date:  -     Revised Date:  2014-10-11    
Medline Journal Info:
Nlm Unique ID:  100898941     Medline TA:  Paediatr Respir Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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