Document Detail


Sudden unexpected death in epilepsy.
MedLine Citation:
PMID:  20446062     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sudden unexpected death in epilepsy (SUDEP) is a significant cause of death for people with epilepsy. Recent research suggests that multiple factors may contribute and that both cardiac and respiratory mechanisms are involved. Both human and animal data suggest that specific genetic factors might play a role in some cases. Recent animal data suggest that serotonin might affect respiratory mechanisms and may be involved. Both cardiac and respiratory abnormalities are more likely with generalized tonic-clonic seizures. Uncontrolled epilepsy, particularly with generalized tonic-clonic seizures, appears to be the most highly associated modifiable risk factor for SUDEP.
Authors:
Maromi Nei; Ryan Hays
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  10     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-27     Completed Date:  2010-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-26     Citation Subset:  IM    
Affiliation:
Jefferson Comprehensive Epilepsy Center, Department of Neurology, Jefferson Medical College, 900 Walnut Street, Suite 200, Philadelphia, PA 19107, USA. maromi.nei@jefferson.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / therapeutic use
Death, Sudden / epidemiology,  etiology*
Diagnosis
Epilepsy / complications*,  drug therapy,  epidemiology,  mortality*
Humans
Risk Factors
Chemical
Reg. No./Substance:
0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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