| Sudden unexpected death in epilepsy. | |
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MedLine Citation:
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PMID: 20446062 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sudden unexpected death in epilepsy (SUDEP) is a significant cause of death for people with epilepsy. Recent research suggests that multiple factors may contribute and that both cardiac and respiratory mechanisms are involved. Both human and animal data suggest that specific genetic factors might play a role in some cases. Recent animal data suggest that serotonin might affect respiratory mechanisms and may be involved. Both cardiac and respiratory abnormalities are more likely with generalized tonic-clonic seizures. Uncontrolled epilepsy, particularly with generalized tonic-clonic seizures, appears to be the most highly associated modifiable risk factor for SUDEP. |
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Authors:
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Maromi Nei; Ryan Hays |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current neurology and neuroscience reports Volume: 10 ISSN: 1534-6293 ISO Abbreviation: Curr Neurol Neurosci Rep Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100931790 Medline TA: Curr Neurol Neurosci Rep Country: United States |
Other Details:
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Languages: eng Pagination: 319-26 Citation Subset: IM |
Affiliation:
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Jefferson Comprehensive Epilepsy Center, Department of Neurology, Jefferson Medical College, 900 Walnut Street, Suite 200, Philadelphia, PA 19107, USA. maromi.nei@jefferson.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / therapeutic use Death, Sudden / epidemiology, etiology* Diagnosis Epilepsy / complications*, drug therapy, epidemiology, mortality* Humans Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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