Document Detail

Sudden unexpected death from oligodendroglioma: a case report and review of the literature.
MedLine Citation:
PMID:  20375839     Owner:  NLM     Status:  In-Data-Review    
ABSTRACT: Sudden and unexpected deaths due to asymptomatic 5 primary brain tumors are extremely rare, with an incidence that ranges from 0.16 to 3.2%. Usually, such tumors are glioblastomas or, less commonly, astrocytomas. Asymptomatic oligodendrogliomas causing sudden death are hardly ever reported among medico-legal investigated cases.We report a rare case of sudden and unexpected death from a previously asymptomatic and undiagnosed, well-differentiated, grade II oligodendrogloioma (WHO classification). According to the autopsy and the microscopic findings brain edema as a result of obstruction of the cerebrospinal fluid flow due to hemorrhagic leakage of the oligodendroglioma is incriminated as the most probable physiopathological mechanism for the sudden death. Diagnosis is mainly based on the special microscopic features of the tumor cells (typical "fried-egg" appearance), interrupted by a dense network of branching capillaries. We discuss further the pathophysiological mechanisms of death and present a short review of literature.
Maria Manousaki; Helen Papadaki; Asteria Papavdi; Elena F Kranioti; Panagiotis Mylonakis; John Varakis; Manolis Michalodimitrakis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of forensic medicine and pathology     Volume:  32     ISSN:  1533-404X     ISO Abbreviation:  Am J Forensic Med Pathol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8108948     Medline TA:  Am J Forensic Med Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  336-40     Citation Subset:  IM    
From the *Department of Forensic Sciences, Medical School, University of Crete, Heraklion, Greece; and †Department of Anatomy-Histology-Embryology, Medical School, University of Patras, Patras, Greece.
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