Document Detail


Sudden Cardiac Death in Hypertrophic Cardiomyopathy.
MedLine Citation:
PMID:  23022709     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hypertrophic cardiomyopathy (HCM) is a common disorder of cardiac muscle associated with sudden cardiac death (SCD). HCM is defined by increased left ventricular wall thickness or mass, in the absence of abnormal loading conditions to account for the observed abnormality.(1) In most adults, the disease is inherited as an autosomal dominant trait and is caused by mutations in cardiac sarcomere protein genes.1 Histologically HCM is characterised by myocardial disarray, fibrosis and small vessel disease.(2) Macroscopically the hypertrophy is typically asymmetric and 25% of patients have resting left ventricular outflow tract obstruction (LVOTO).(3)...
Authors:
Constantinos O'Mahony; Perry Elliott; William McKenna
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The Heart Hospital & University College London, London, United Kingdom.
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