| Sudden cardiac death after myocardial infarction in patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 20682359 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Type 2 diabetes mellitus is a well-established risk factor for atherosclerosis, but its contribution to sudden cardiac death (SCD) risk after myocardial infarction (MI) is not well defined. OBJECTIVE: The purpose of this study was to compare the incidence and time-dependent risk of SCD in diabetic patients versus nondiabetic patients during 5-year follow-up after acute MI. METHODS: A total of 3,276 patients were enrolled at the time of acute MI between 1996 and 2005. Mean age at entry was 60 ± 11 years, and the cohort was followed until 2009. At entry into the study, diabetes was present in 629 (19.2%) patients. The primary endpoint was SCD, and the secondary endpoints were non-SCD and all-cause mortality. RESULTS: Among diabetic patients, the incidence of SCD was higher (5.9%) than in nondiabetic patients (1.7%), with a hazard ratio (HR) of 3.8 (95% confidence interval [CI] 2.4-5.8; P <.001) and adjusted HR of 2.3 (95% CI 1.4-3.8; P <.01). In diabetic patients with left ventricular ejection fraction >35%, the incidence of SCD was nearly identical to that of nondiabetic patients with ventricular ejection fraction ≤35% (4.1% vs 4.9%; P = .48). An excess in the incidence of non-SCD began to appear among diabetic patients within the first 6 months of follow-up (P <.001) but not in the incidence of SCD (P = .09). The excess in SCD among diabetic patients began to appear more than 6 months after the index event. CONCLUSION: Patients with type 2 diabetes are at higher risk for SCD after MI than are nondiabetic patients. The incidence of SCD in post-MI type 2 diabetic patients with left ventricular ejection fraction >35% is equal to that of nondiabetic patients with left ventricular ejection fraction <35%. |
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Authors:
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M Juhani Junttila; Petra Barthel; Robert J Myerburg; Timo H Mäkikallio; Axel Bauer; Kurt Ulm; Antti Kiviniemi; Mikko Tulppo; Juha S Perkiömäki; Georg Schmidt; Heikki V Huikuri |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-01 |
Journal Detail:
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Title: Heart rhythm : the official journal of the Heart Rhythm Society Volume: 7 ISSN: 1556-3871 ISO Abbreviation: Heart Rhythm Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200317 Medline TA: Heart Rhythm Country: United States |
Other Details:
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Languages: eng Pagination: 1396-403 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland. jjunttila@med.miami.edu |
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Comment In:
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Heart Rhythm. 2010 Oct;7(10):1404-5
[PMID:
20797459
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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