Document Detail


Sudan black B positivity in acute lymphoblastic leukemia.
MedLine Citation:
PMID:  1542637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 146 patients with newly diagnosed acute lymphoblastic leukemia (ALL) occurring over a 9 1/2-yr period were reviewed; four of these patients (2.7%) had blast cells that stained positively with Sudan Black B. These four, two adults and two children, were all B type. Electron microscopy was performed on three of these four cases and showed the sudanophilia to be due to lipid droplets. The lipid droplets were also demonstrated in one of the three cases by Oil Red O stain. Therefore, Sudan Black B used alone to differentiate lymphoid from myeloid leukemia may be misleading.
Authors:
M Ngan; K Chien; S Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  5     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-04-09     Completed Date:  1992-04-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-70     Citation Subset:  IM    
Affiliation:
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
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MeSH Terms
Descriptor/Qualifier:
Adult
Azo Compounds / diagnostic use*
Bone Marrow / pathology,  ultrastructure
Child
Female
Hematopoietic Stem Cells / pathology,  ultrastructure
Histocytochemistry / methods
Humans
Immunophenotyping
Leukemia, Myeloid / diagnosis*,  pathology
Lymphocytes / pathology,  ultrastructure
Male
Microscopy, Electron
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*,  pathology
Chemical
Reg. No./Substance:
0/Azo Compounds; 4197-25-5/Sudan Black B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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