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Sucrose, high-sugar foods and risk of endometrial cancer - a population-based cohort study.
MedLine Citation:
PMID:  21765006     Owner:  NLM     Status:  Publisher    
BackgroundConsumption of high-sugar foods stimulates insulin production, which has been associated with endometrial cancer. Although a relationship between sucrose, high-sugar food consumption and endometrial cancer risk is biologically plausible, this hypothesis has previously been explored in very few studies.MethodsWe used data from the Swedish Mammography Cohort, including 61 226 women aged 40-74 years. We examined the association between consumption of total sucrose, high-sugar foods (at baseline 1987-90 and 1997) and endometrial cancer risk using Cox proportional hazards models to estimate incidence rate ratios (RR) with 95% confidence intervals (CI). Results During 18.4 years of follow-up, 729 participants were diagnosed with incident endometrial cancer. Total sucrose intake and consumption of sweet buns and cookies was associated with increased risk of endometrial cancer. RRs (with 95% CIs) for consuming more than 35 grams of sucrose/day and consuming sweet buns and cookies more than 3 times/week were 1.36 (1.04-1.77) and 1.42 (1.15-1.75) as compared to less than 15 grams of sucrose/day and consuming sweet buns and cookies less than 0.5 times/week, respectively. RRs for consuming more than 15 grams of sucrose/day as compared to 15 grams or less were 1.97 (1.27-3.04) among obese women and 1.56 (1.20-2.04) among women with low fat intake.ConclusionsThese data indicate that sucrose intake and consumption of sweet buns and cookies may be associated with increased risk of endometrial cancer. ImpactGiven the high intake of sweetened foods, these results have public health implications in terms of prevention of endometrial cancer.
Emilie Friberg; Alice Wallin; Alicja Wolk
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-15
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  -     ISSN:  1538-7755     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Clinical Neuroscience, Karolinska Institutet.
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