Document Detail


Sucralfate versus alginate/antacid in the treatment of peptic esophagitis.
MedLine Citation:
PMID:  2821808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty patients in whom endoscopy revealed peptic esophagitis were included in a double-blind study in which either sucralfate (1 g four times a day) or an alginate/antacid compound (5 g four times a day) were randomly assigned. After six weeks of treatment, efficacy and clinical safety were evaluated in 23 patients in the sucralfate group and 22 patients in the alginate/antacid group. No significant difference between the two treatments was detected with regard to efficacy, evaluated on the basis of clinical and endoscopic criteria. Clinical safety was also good in both groups. Sucralfate was, therefore, found to be as effective and as well tolerated as the alginate/antacid compound in the treatment of peptic esophagitis.
Authors:
M Evreux
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of medicine     Volume:  83     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-11-02     Completed Date:  1987-11-02     Revised Date:  2010-07-07    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  48-50     Citation Subset:  AIM; IM    
Affiliation:
Gastro-Enterology Department, Hotel-Dieu, Lyon, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alginates / therapeutic use*
Aluminum Hydroxide / therapeutic use*
Antacids / therapeutic use*
Bicarbonates / therapeutic use*
Clinical Trials as Topic
Double-Blind Method
Drug Combinations / therapeutic use
Endoscopy
Esophagitis, Peptic / drug therapy*,  pathology
Female
Humans
Male
Middle Aged
Random Allocation
Silicic Acid / therapeutic use*
Silicon Dioxide / therapeutic use*
Sodium Bicarbonate*
Sucralfate / therapeutic use*
Chemical
Reg. No./Substance:
0/Alginates; 0/Antacids; 0/Bicarbonates; 0/Drug Combinations; 1343-98-2/Silicic Acid; 144-55-8/Sodium Bicarbonate; 21645-51-2/Aluminum Hydroxide; 54182-58-0/Sucralfate; 66220-44-8/alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination; 7631-86-9/Silicon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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