Document Detail


Sucralfate suspension as a treatment of recurrent aphthous stomatitis.
MedLine Citation:
PMID:  8077892     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
DESIGN: A prospective randomized, double-blind, placebo-controlled, cross-over clinical trial. SETTING: A university hospital. SUBJECTS: Twenty-one patients with symptomatic recurrent aphthous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups. INTERVENTION: In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years. RESULTS: After 2 years of follow-up, sucralfate was found to be superior to both placebo and antacid (P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission. CONCLUSION: Sucralfate suspension should be added to the armament of treatment modalities of RAS.
Authors:
J Rattan; M Schneider; N Arber; M Gorsky; D Dayan
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of internal medicine     Volume:  236     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-30     Completed Date:  1994-09-30     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  341-3     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Tel Aviv Medical Centre, Sackler School of Medicine, Israel.
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MeSH Terms
Descriptor/Qualifier:
Administration, Buccal
Adolescent
Adult
Aged
Antacids / therapeutic use
Child
Child, Preschool
Double-Blind Method
Female
Humans
Male
Middle Aged
Prospective Studies
Recurrence
Stomatitis, Aphthous / drug therapy*
Sucralfate / administration & dosage,  therapeutic use*
Suspensions
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antacids; 0/Suspensions; 54182-58-0/Sucralfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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