| Sucralfate for the prevention of early rebleeding following injection sclerotherapy for esophageal varices. | |
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MedLine Citation:
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PMID: 2788116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred eighty patients with variceal bleeding and treated by long-term sclerotherapy were randomized into a prospective randomized controlled clinical trial to assess the efficacy of sucralfate in reducing the frequency of rebleeding from esophageal ulceration prior to variceal obliteration. Overall, 29 (32%) of the 92 patients treated with the addition of sucralfate rebled, compared to 37 (42%) of 88 patients managed by sclerotherapy alone (p less than 0.10), but when patients with well-compensated liver disease were considered, the respective figures were 14 (24%) and 25 (42%)--a statistically significant difference (p less than 0.05). The frequency (approximately 70%), number (per patient) and extent of sclerotherapy-induced esophageal mucosal ulceration were not different for the two groups, although proven rebleeding from the ulceration occurred less frequently in those receiving sucralfate (10 and 20 occasions, respectively, p less than 0.05). Mortality was not different for the two groups. Thus, use of sucralfate will reduce the frequency of rebleeding during long-term treatment by sclerotherapy, although benefit appears to be restricted to well-compensated patients and without an endoscopic overt effect upon esophageal mucosal ulceration. |
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Authors:
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R J Polson; D Westaby; A E Gimson; P C Hayes; A J Stellon; K Hayllar; R Williams |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Hepatology (Baltimore, Md.) Volume: 10 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1989-09-21 Completed Date: 1989-09-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 279-82 Citation Subset: IM |
Affiliation:
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Liver Unit, King's College Hospital, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Combined Modality Therapy Esophageal Diseases / etiology Esophageal and Gastric Varices / etiology, mortality, therapy* Female Gastritis / etiology Gastrointestinal Hemorrhage / etiology, mortality, therapy* Humans Liver Diseases / complications, pathology Male Middle Aged Recurrence Sclerosing Solutions / adverse effects, therapeutic use* Sucralfate / adverse effects, therapeutic use* Time Factors Ulcer / etiology |
| Chemical | |
Reg. No./Substance:
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0/Sclerosing Solutions; 54182-58-0/Sucralfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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