Document Detail

Sucralfate for the prevention of early rebleeding following injection sclerotherapy for esophageal varices.
MedLine Citation:
PMID:  2788116     Owner:  NLM     Status:  MEDLINE    
One hundred eighty patients with variceal bleeding and treated by long-term sclerotherapy were randomized into a prospective randomized controlled clinical trial to assess the efficacy of sucralfate in reducing the frequency of rebleeding from esophageal ulceration prior to variceal obliteration. Overall, 29 (32%) of the 92 patients treated with the addition of sucralfate rebled, compared to 37 (42%) of 88 patients managed by sclerotherapy alone (p less than 0.10), but when patients with well-compensated liver disease were considered, the respective figures were 14 (24%) and 25 (42%)--a statistically significant difference (p less than 0.05). The frequency (approximately 70%), number (per patient) and extent of sclerotherapy-induced esophageal mucosal ulceration were not different for the two groups, although proven rebleeding from the ulceration occurred less frequently in those receiving sucralfate (10 and 20 occasions, respectively, p less than 0.05). Mortality was not different for the two groups. Thus, use of sucralfate will reduce the frequency of rebleeding during long-term treatment by sclerotherapy, although benefit appears to be restricted to well-compensated patients and without an endoscopic overt effect upon esophageal mucosal ulceration.
R J Polson; D Westaby; A E Gimson; P C Hayes; A J Stellon; K Hayllar; R Williams
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  10     ISSN:  0270-9139     ISO Abbreviation:  Hepatology     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-09-21     Completed Date:  1989-09-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-82     Citation Subset:  IM    
Liver Unit, King's College Hospital, London, United Kingdom.
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MeSH Terms
Combined Modality Therapy
Esophageal Diseases / etiology
Esophageal and Gastric Varices / etiology,  mortality,  therapy*
Gastritis / etiology
Gastrointestinal Hemorrhage / etiology,  mortality,  therapy*
Liver Diseases / complications,  pathology
Middle Aged
Sclerosing Solutions / adverse effects,  therapeutic use*
Sucralfate / adverse effects,  therapeutic use*
Time Factors
Ulcer / etiology
Reg. No./Substance:
0/Sclerosing Solutions; 54182-58-0/Sucralfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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