| Sucralfate maintenance therapy in reflux esophagitis. Sucralfate Investigational Working Team. | |
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MedLine Citation:
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PMID: 7639221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: to prove in a double-blind placebo-controlled multinational trial the effects of sucralfate suspension 2 g BID and placebo in the prevention of recurrent reflux esophagitis. METHODS: One hundred and eighty-four patients from 16 centers with reflux esophagitis Savary grade 1 and 2 were initially healed with antisecretory therapy before entering the study. They were randomly allocated to sucralfate suspension 2 g BID or placebo for 6 months. Symptoms were monitored monthly. Endoscopy was performed at the end of the trial or earlier in case of clinical suspension of relapse. RESULTS: The two treatment groups were well matched. We were able to analyze 88 sucralfate- and 93 placebo-treated patients. There was a significant reduction in the endoscopic relapse rate (31% in the sucralfate group vs. 65% in the placebo group, p < 0.001). This reduction was especially obvious for symptomatic relapses (10% vs. 34%, respectively, p < 0.001). CONCLUSION: This is the first study to show that sucralfate suspension is capable of preventing recurrent reflux esophagitis in patients with solitary or confluent erosions previously healed with antisecretory therapy. |
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Authors:
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G N Tytgat; H R Koelz; G D Vosmaer |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 90 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-08 Completed Date: 1995-09-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1233-7 Citation Subset: IM |
Affiliation:
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Academic Medical Center, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Double-Blind Method Drug Administration Schedule Esophagitis, Peptic / drug therapy*, epidemiology Esophagoscopy Female Follow-Up Studies Humans Life Tables Male Middle Aged Recurrence Sucralfate / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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54182-58-0/Sucralfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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