Document Detail

Sucralfate maintenance therapy in reflux esophagitis. Sucralfate Investigational Working Team.
MedLine Citation:
PMID:  7639221     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: to prove in a double-blind placebo-controlled multinational trial the effects of sucralfate suspension 2 g BID and placebo in the prevention of recurrent reflux esophagitis. METHODS: One hundred and eighty-four patients from 16 centers with reflux esophagitis Savary grade 1 and 2 were initially healed with antisecretory therapy before entering the study. They were randomly allocated to sucralfate suspension 2 g BID or placebo for 6 months. Symptoms were monitored monthly. Endoscopy was performed at the end of the trial or earlier in case of clinical suspension of relapse. RESULTS: The two treatment groups were well matched. We were able to analyze 88 sucralfate- and 93 placebo-treated patients. There was a significant reduction in the endoscopic relapse rate (31% in the sucralfate group vs. 65% in the placebo group, p < 0.001). This reduction was especially obvious for symptomatic relapses (10% vs. 34%, respectively, p < 0.001). CONCLUSION: This is the first study to show that sucralfate suspension is capable of preventing recurrent reflux esophagitis in patients with solitary or confluent erosions previously healed with antisecretory therapy.
G N Tytgat; H R Koelz; G D Vosmaer
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  90     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-08     Completed Date:  1995-09-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1233-7     Citation Subset:  IM    
Academic Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Double-Blind Method
Drug Administration Schedule
Esophagitis, Peptic / drug therapy*,  epidemiology
Follow-Up Studies
Life Tables
Middle Aged
Sucralfate / therapeutic use*
Time Factors
Reg. No./Substance:

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