| Sucralfate in the treatment of reflux esophagitis in adults: an update. | |
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MedLine Citation:
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PMID: 2662389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sucralfate was evaluated in several clinical studies on reflux esophagitis, a total of over 400 patients were studied worldwide. In this study 49 patients with reflux esophagitis of stage I-III acc. to Savary and Miller were included. The evaluation was based on 41 patients, 22 received sucralfate suspension 1 g in 5 ml qid, 19 ranitidine 150 mg bid. The patients were treated for 8 weeks, endoscopic controls were performed before treatment and after 8 weeks. The healing rates were 64% in the sucralfate group and 68% in the ranitidine group and exhibited no significant difference (p greater than 0.05). Antacid consumption and symptomatic improvement were comparable in both groups. Sucralfate seems to be a valid alternative to H2-blockers in the treatment of reflux esophagitis. |
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Authors:
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B Simon; H G Dammann; P Müller |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 156 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-08-08 Completed Date: 1989-08-08 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 37-41 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Kreiskrankenhaus, Schwetzingen, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Esophagitis, Peptic / drug therapy* Female Humans Male Multicenter Studies as Topic Random Allocation Ranitidine / administration & dosage, therapeutic use* Sucralfate / administration & dosage, therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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54182-58-0/Sucralfate; 66357-35-5/Ranitidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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