| Succinylcholine does not increase serum potassium levels in patients with acutely ruptured cerebral aneurysms. | |
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MedLine Citation:
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PMID: 2301749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Succinylcholine-induced hyperkalemia has been reported to occur in many neurological disorders including subarachnoid hemorrhage. The purpose of this study was to compare the effect of succinylcholine on serum potassium levels in patients with ruptured cerebral aneurysms undergoing either early (less than or equal to 4 days; n = 14) or delayed (5-16 days; n = 20) surgery. Thirty-four patients were classified according to the number of days from subarachnoid hemorrhage to surgery. Arterial serum potassium levels were measured after induction of anesthesia but before succinylcholine, and 1, 5, and 10 min after the administration of succinylcholine. The electrocardiogram was continuously monitored. The mean ( +/- SD) increase in serum potassium level of 0.4 +/- 0.2 mmol/L occurred at 10 min but was not statistically significant, nor was there any statistically significant difference in serum potassium levels related to time between subarachnoid hemorrhage and administration of succinylcholine. We found no evidence of succinylcholine-induced hyperkalemia in patients undergoing either early or delayed cerebral aneurysm surgery. |
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Authors:
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P H Manninen; B Mahendran; A W Gelb; R N Merchant |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 70 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-02-26 Completed Date: 1990-02-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 172-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Anaesthesia, University Hospital, London, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Hyperkalemia / chemically induced Intracranial Aneurysm / blood*, surgery Male Middle Aged Potassium / blood* Rupture, Spontaneous Subarachnoid Hemorrhage / blood, surgery Succinylcholine / adverse effects* Tubocurarine / pharmacology |
| Chemical | |
Reg. No./Substance:
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306-40-1/Succinylcholine; 57-95-4/Tubocurarine; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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