Document Detail

Succinylcholine does not increase serum potassium levels in patients with acutely ruptured cerebral aneurysms.
MedLine Citation:
PMID:  2301749     Owner:  NLM     Status:  MEDLINE    
Succinylcholine-induced hyperkalemia has been reported to occur in many neurological disorders including subarachnoid hemorrhage. The purpose of this study was to compare the effect of succinylcholine on serum potassium levels in patients with ruptured cerebral aneurysms undergoing either early (less than or equal to 4 days; n = 14) or delayed (5-16 days; n = 20) surgery. Thirty-four patients were classified according to the number of days from subarachnoid hemorrhage to surgery. Arterial serum potassium levels were measured after induction of anesthesia but before succinylcholine, and 1, 5, and 10 min after the administration of succinylcholine. The electrocardiogram was continuously monitored. The mean ( +/- SD) increase in serum potassium level of 0.4 +/- 0.2 mmol/L occurred at 10 min but was not statistically significant, nor was there any statistically significant difference in serum potassium levels related to time between subarachnoid hemorrhage and administration of succinylcholine. We found no evidence of succinylcholine-induced hyperkalemia in patients undergoing either early or delayed cerebral aneurysm surgery.
P H Manninen; B Mahendran; A W Gelb; R N Merchant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  70     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-02-26     Completed Date:  1990-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  172-5     Citation Subset:  AIM; IM    
Department of Anaesthesia, University Hospital, London, Ontario, Canada.
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MeSH Terms
Hyperkalemia / chemically induced
Intracranial Aneurysm / blood*,  surgery
Middle Aged
Potassium / blood*
Rupture, Spontaneous
Subarachnoid Hemorrhage / blood,  surgery
Succinylcholine / adverse effects*
Tubocurarine / pharmacology
Reg. No./Substance:
306-40-1/Succinylcholine; 57-95-4/Tubocurarine; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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