Document Detail

Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.
MedLine Citation:
PMID:  22014567     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells.
Lisa Kinch; Nick V Grishin; James Brugarolas
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cancer cell     Volume:  20     ISSN:  1878-3686     ISO Abbreviation:  Cancer Cell     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-21     Completed Date:  2012-02-14     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  101130617     Medline TA:  Cancer Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  418-20     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Grant Support
R01 CA129387/CA/NCI NIH HHS; R01 CA129387-05/CA/NCI NIH HHS
Comment On:
Cancer Cell. 2011 Oct 18;20(4):524-37   [PMID:  22014577 ]
Cancer Cell. 2011 Oct 18;20(4):511-23   [PMID:  22014576 ]

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