| Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2. | |
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MedLine Citation:
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PMID: 22014567 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells. |
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Authors:
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Lisa Kinch; Nick V Grishin; James Brugarolas |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Cancer cell Volume: 20 ISSN: 1878-3686 ISO Abbreviation: Cancer Cell Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-21 Completed Date: 2012-02-14 Revised Date: 2013-02-19 |
Medline Journal Info:
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Nlm Unique ID: 101130617 Medline TA: Cancer Cell Country: United States |
Other Details:
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Languages: eng Pagination: 418-20 Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 CA129387/CA/NCI NIH HHS; R01 CA129387-05/CA/NCI NIH HHS |
| Comments/Corrections | |
Comment On:
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Cancer Cell. 2011 Oct 18;20(4):524-37
[PMID:
22014577
]
Cancer Cell. 2011 Oct 18;20(4):511-23 [PMID: 22014576 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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