Document Detail


Succinate synthesis and excretion by Penicillium simplicissimum under aerobic and anaerobic conditions.
MedLine Citation:
PMID:  12044678     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Succinate is an interesting chemical for industries producing food and pharmaceutical products, surfactants, detergents and biodegradable plastics. Succinate is produced mainly by a mixed-acid fermentation process using anaerobically growing bacteria. However, succinate excretion is also widespread among fungi. In this article we report results on the intracellular concentration and the excretion of succinate by Penicillium simplicissimum under aerobic and anaerobic conditions. The intracellular concentration of succinate increased slightly with the specific growth rate and strongly if the respiratory chain was inhibited by sodium azide or anaerobic conditions (N(2)). A strong increase of succinate excretion was observed if the respiratory chain was inhibited. It is suggested that succinate synthesis under functional (sodium azide) or environmental (N(2)) anaerobic conditions occurs via the reductive part of the tricarboxylic acid cycle. Succinate is then excreted because the oxidative part of the tricarboxylic acid cycle is inactive. A possible role of succinate synthesis in the regeneration of NAD ('fumarate respiration') is discussed.
Authors:
Martin Gallmetzer; Joachim Meraner; Wolfgang Burgstaller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEMS microbiology letters     Volume:  210     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-04     Completed Date:  2003-02-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  221-5     Citation Subset:  IM    
Affiliation:
Institute of Microbiology, Technikerstrasse 25, 6020 Innsbruck, Austria. martin.gallmetzer@uibk.ac.at
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Aerobiosis
Anaerobiosis
Cell Respiration
Citric Acid / metabolism
Citric Acid Cycle
Fumarates / metabolism
Gene Expression
Glucose / metabolism
Oxidation-Reduction
Penicillium / growth & development,  metabolism*
Quaternary Ammonium Compounds / metabolism
Succinates / metabolism*
Tricarboxylic Acids / metabolism
Chemical
Reg. No./Substance:
0/Fumarates; 0/Quaternary Ammonium Compounds; 0/Succinates; 0/Tricarboxylic Acids; 50-99-7/Glucose; 56-65-5/Adenosine Triphosphate; 77-92-9/Citric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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