Document Detail


Succinate dehydrogenase - Assembly, regulation and role in human disease.
MedLine Citation:
PMID:  20226277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Succinate dehydrogenase (or Electron Transport Chain Complex II) has been the subject of a focused but significant renaissance. This complex, which has been the least studied of the mitochondrial respiratory complexes has seen renewed interest due to the discovery of its role in human disease. Under this heightened scrutiny, the succinate dehydrogenase complex has proven to be a fascinating machine, whose regulation and assembly requires additional factors that are beginning to be discovered. Mutations in these factors and in the structural subunits of the complex itself cause a variety of human diseases. The mechanisms underlying the pathogenesis of SDH mutations is beginning to be understood.
Authors:
Jared Rutter; Dennis R Winge; Joshua D Schiffman
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-10
Journal Detail:
Title:  Mitochondrion     Volume:  10     ISSN:  1872-8278     ISO Abbreviation:  Mitochondrion     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-08-18     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  100968751     Medline TA:  Mitochondrion     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  393-401     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Mitochondria Research Society. Published by Elsevier B.V. All rights reserved.
Affiliation:
Departments of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, United States. rutter@biochem.utah.edu
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MeSH Terms
Descriptor/Qualifier:
Gene Expression Regulation*
Genetic Diseases, Inborn / enzymology*
Humans
Mitochondrial Proteins / biosynthesis*,  chemistry,  deficiency*
Succinate Dehydrogenase / biosynthesis*,  chemistry,  deficiency*
Grant Support
ID/Acronym/Agency:
R01 ES003817-30/ES/NIEHS NIH HHS; R01 GM087346-02/GM/NIGMS NIH HHS; R01 GM087346-03/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Mitochondrial Proteins; EC 1.3.99.1/Succinate Dehydrogenase
Comments/Corrections

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