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Successive B-cell lymphomas mostly reflect recurrences rather than unrelated primary lymphomas.
MedLine Citation:
PMID:  23765542     Owner:  NLM     Status:  In-Data-Review    
Objectives: To address whether successive B-cell lymphomas, diagnosed within a 5- to 15-year interval, are recurrences or unrelated primary lymphomas. Methods: Immunoglobulin heavy and κ light chain gene rearrangements were studied using multiplex polymerase chain reaction fragment assays and sequence analysis in 61 patients. Results: Clonal patterns of the multiple lymphomas from 36 patients were determined and classified accordingly: 30 recurrences, 2 possible recurrences, 2 different clones with a common origin, and 2 unrelated primary lymphomas. Conclusions: Regardless of subtype, 89% to 94% of late B-cell lymphoma relapses were recurrences of the primary tumor. Therefore, routinely investigating the possible clonal relationship between successive lymphomas may not be warranted except for specific lymphoma subtypes such as diffuse large B-cell lymphomas.
Willemina R R Geurts-Giele; Ingrid L M Wolvers-Tettero; Winand N M Dinjens; King H Lam; Anton W Langerak
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  140     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  114-26     Citation Subset:  AIM; IM    
Dept. of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, the Netherlands;
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