Document Detail

Successfully treated sulphasalazine-induced fulminant hepatic failure, thrombocytopenia and erythroid hypoplasia with intravenous immunoglobulin.
MedLine Citation:
PMID:  9776124     Owner:  NLM     Status:  MEDLINE    
We report the simultaneous development of fulminant hepatic failure, thrombocytopenia and erythroid hypoplasia in a child treated with sulphasalazine. A 12-year-old girl with juvenile rheumatoid arthritis developed fulminant hepatic failure, thrombocytopenia and erythroid hypoplasia, which was confirmed by liver histology and bone marrow examination, 2 weeks after initiation of sulphasalazine therapy. The patient recovered after administration of high doses of intravenous immunoglobulin. This is the first reported case of the concurrent development of these complications associated with sulphasalazine hypersensitivity. The use of intravenous immunoglobulin may have helped in the treatment of this rare adverse effect of sulphasalazine.
J L Huang; I J Hung; L C Chen; W Y Lee; C Hsueh; K H Hsieh
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical rheumatology     Volume:  17     ISSN:  0770-3198     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-15     Completed Date:  1998-12-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  349-52     Citation Subset:  IM    
Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung University, Taoyuan, Taiwan.
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MeSH Terms
Antirheumatic Agents / adverse effects*
Arthritis, Juvenile Rheumatoid / drug therapy
Follow-Up Studies
Hepatic Encephalopathy / chemically induced,  complications,  therapy*
Immunoglobulins, Intravenous / therapeutic use*
Red-Cell Aplasia, Pure / chemically induced,  complications,  therapy*
Sulfasalazine / adverse effects*
Thrombocytopenia / chemically induced,  complications,  therapy*
Reg. No./Substance:
0/Antirheumatic Agents; 0/Immunoglobulins, Intravenous; 599-79-1/Sulfasalazine

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