Document Detail

A Successfully Resected Case of Recurrent Lung and Liver Metastases of Rectal Cancer Treated with XELIRI + Bevacizumab Therapy.
MedLine Citation:
PMID:  23569449     Owner:  NLM     Status:  PubMed-not-MEDLINE    
It has been reported that many colorectal cancer (CRC) patients with synchronous or metachronous liver metastases underwent surgery subsequent to neoadjuvant combination chemotherapy with folinic acid, fluorouracil, and oxaliplatin (FOLFOX), folinic acid, fluorouracil, and irinotecan (FOLFIRI), or capecitabine and oxaliplatin (XELOX). However, there are very few reports of the use of capecitabine and irinotecan (XELIRI). We herein report a successfully resected case of recurrent lung and liver metastases of rectal cancer treated with combination chemotherapy with XELIRI + bevacizumab (BV) therapy. A 63-year-old male developed recurrence of a solitary nodule in the right lower lobe of the lung and multiple liver metastases after low anterior resection for rectal cancer 1 year previously. Partial resection of the right lower lobe of the lung was performed and treatment with XELIRI + BV was initiated. A computed tomography scan revealed a reduction in tumor size without any new lesions after four cycles of XELIRI + BV therapy. Partial hepatectomy of S1, S5, and S7 was safely performed. The patient is now undergoing adjuvant chemotherapy and has been free from recurrence for 18 months following surgery. There are only few studies with relatively low patient numbers reporting on the outcome after resection of both pulmonary and hepatic metastases of CRC. We therefore report a patient who underwent sequential resection of pulmonary and hepatic metastases with XELIRI + BV therapy.
Naoya Aisu; Yoichiro Yoshida; Fuminori Ishii; Toru Miyake; Shu Tanimura; Yoshito Wada; Yasushi Yamauchi; Seiichiro Hoshino; Tomoaki Noritomi; Yuichi Yamashita
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Publication Detail:
Type:  Journal Article     Date:  2013-03-06
Journal Detail:
Title:  Case reports in oncology     Volume:  6     ISSN:  1662-6575     ISO Abbreviation:  Case Rep Oncol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-04-09     Completed Date:  2013-04-10     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  101517601     Medline TA:  Case Rep Oncol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  -    
Department of Gastroenterological Surgery, Fukuoka University Graduate School of Medicine, Fukuoka, Japan.
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