| Successful uterine transplantation in the mouse: pregnancy and post-natal development of offspring. | |
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MedLine Citation:
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PMID: 14507815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Uterine transplantation could serve as a tool in studies of the physiology of implantation/pregnancy, and is also a possible future treatment for patients with absolute uterine infertility. Here, the first live-born offspring in any uterine transplantation model is reported. METHODS: A syngeneic mouse model with a uterus transplanted, by end-to-side aorta/vena cava vascular anastomoses, alongside the native uterus was used. The cervix was attached to a cutaneous stoma. Pregnancy rate and offspring (birth weight, growth and fertility) was evaluated after blastocyst transfer to the native and the grafted uterus of transplanted mice and to controls. RESULTS: Pregnancy rates were comparable in the grafted uterus (8/12 animals became pregnant) and the native uterus (9/12 pregnant) of transplanted animals and controls (8/13 pregnant). In a separate set of animals, the native uterus was removed at transplantation to exclude influences from the native uterus on the pregnancy potential of the graft; two of four animals became pregnant after blastocyst transfer. The weights/lengths of fetuses (gestational day 18) and gestational lengths were similar in all groups. Offspring were delivered and the growth trajectories (up to 8 weeks) of offspring delivered from grafted or native uteri of transplanted mice were similar as compared with controls, and all were fertile. The second-generation offspring from transplanted animals were all fertile with normal birth weights. CONCLUSIONS: These observations document the capacity of a transplanted uterus to harbour pregnancies to term, and reveal that offspring from a transplanted uterus develop to normal fertile adults. |
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Authors:
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Randa Racho El-Akouri; Göran Kurlberg; Mats Brännström |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 18 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-25 Completed Date: 2004-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2018-23 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, The Sahlgrenska Academy at Göteborg University, Göteborg, Sweden. randa.racho@obgyn.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / growth & development*, physiology Female Fertility Fetal Weight Labor, Obstetric Mice Mice, Inbred Strains Organ Size Parturition Placenta / anatomy & histology Pregnancy Pregnancy, Animal* Uterus / transplantation* |
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