Document Detail

Successful use of vaginal sildenafil citrate in two infertility patients with Asherman's syndrome.
MedLine Citation:
PMID:  16724891     Owner:  NLM     Status:  MEDLINE    
Vaginal sildenafil citrate (Viagra, Pfizer, Inc., New York, NY) has been shown to be useful in increasing endometrial thickness and achieving pregnancy in women with varied uterine disorders. However, it failed to demonstrate favorable results in the setting of Asherman's syndrome, a condition characterized by the presence of uterine synechiae. We have successfully applied this treatment in two women noted to have inadequate endometrium after surgical resection of uterine synechiae. Both patients had a history of a postpartum uterine curettage with subsequent secondary infertility. Asherman's syndrome was surgically demonstrated and treated in both patients. Postoperatively, both patients were noted to have a thin endometrium and failed to conceive despite fertility treatment. Subsequently, these women achieved pregnancy in the first treatment cycle with vaginal sildenafil citrate. Using transvaginal ultrasound, endometrial thickness was noted to improve when sildenafil citrate was administered. It is suspected that this medication causes selective vasodilatation, resulting in improved endometrial development.
Michael Zinger; James H Liu; Michael A Thomas
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of women's health (2002)     Volume:  15     ISSN:  1540-9996     ISO Abbreviation:  J Womens Health (Larchmt)     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-26     Completed Date:  2006-11-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101159262     Medline TA:  J Womens Health (Larchmt)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA.
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MeSH Terms
Administration, Intravaginal
Endometrium / blood supply*,  drug effects
Gynatresia / complications,  drug therapy*
Infertility, Female / drug therapy*,  etiology
Piperazines / administration & dosage*
Treatment Outcome
Vasodilator Agents / administration & dosage*
Women's Health
Reg. No./Substance:
0/Piperazines; 0/Purines; 0/Sulfones; 0/Vasodilator Agents; 139755-83-2/sildenafil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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