Document Detail


Successful use of steroids and ureteric stents in 24 patients with idiopathic retroperitoneal fibrosis: a retrospective study.
MedLine Citation:
PMID:  18332635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Retroperitoneal fibrosis (RPF) is a chronic inflammatory disorder causing obstructive nephropathy and renal failure. We reviewed our management of this condition. METHOD: All patients with RPF treated at a single center over a 15-year period were identified. A full review of notes and computer records was undertaken. RESULTS: Data was available on 27 patients, 3 of which were excluded from later analysis. Diagnosis was based on clinical history and cross-sectional imaging. Retroperitoneal biopsy was undertaken in 3 patients. 96% had significant renal impairment at presentation with a mean serum creatinine of 688 micromol/l. 46% required emergency hemodialysis. All patients were treated with a combination of ureteric stents and/or steroids with an excellent clinical response. The mean best creatinine reached by the cohort was 136 micromol/l, and renal function remained stable in the long term. No patients required chronic dialysis. Ureteric stents were removed within 12 months and low-dose steroids were continued for a mean of 34 months. Recurrent disease was observed in 25% of patients, who all responded well to further steroid therapy. Mean duration of follow-up was 76 months. CONCLUSIONS: RPF is very effectively treated by a combination of ureteric stents and steroids, with excellent long-term results using this approach. Continued follow-up is advised because of the possibility of recurrent disease.
Authors:
Andrew C Fry; Sadmeet Singh; Smita S Gunda; Greg B Boustead; Damian C Hanbury; Thomas A McNicholas; Ken Farrington
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Publication Detail:
Type:  Journal Article     Date:  2008-03-07
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  108     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2008  
Date Detail:
Created Date:  2008-04-24     Completed Date:  2008-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c213-20     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Affiliation:
Department of Nephrology, Lister Hospital, Stevenage, UK. andyfry@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Inflammatory Agents / therapeutic use
Combined Modality Therapy
Female
Humans
Male
Middle Aged
Retroperitoneal Fibrosis / complications,  diagnosis,  therapy*
Retrospective Studies
Steroids / therapeutic use*
Treatment Outcome
Ureter / surgery*
Ureteral Obstruction / diagnosis,  etiology,  therapy*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Steroids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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