| Successful use of steroids and ureteric stents in 24 patients with idiopathic retroperitoneal fibrosis: a retrospective study. | |
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MedLine Citation:
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PMID: 18332635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Retroperitoneal fibrosis (RPF) is a chronic inflammatory disorder causing obstructive nephropathy and renal failure. We reviewed our management of this condition. METHOD: All patients with RPF treated at a single center over a 15-year period were identified. A full review of notes and computer records was undertaken. RESULTS: Data was available on 27 patients, 3 of which were excluded from later analysis. Diagnosis was based on clinical history and cross-sectional imaging. Retroperitoneal biopsy was undertaken in 3 patients. 96% had significant renal impairment at presentation with a mean serum creatinine of 688 micromol/l. 46% required emergency hemodialysis. All patients were treated with a combination of ureteric stents and/or steroids with an excellent clinical response. The mean best creatinine reached by the cohort was 136 micromol/l, and renal function remained stable in the long term. No patients required chronic dialysis. Ureteric stents were removed within 12 months and low-dose steroids were continued for a mean of 34 months. Recurrent disease was observed in 25% of patients, who all responded well to further steroid therapy. Mean duration of follow-up was 76 months. CONCLUSIONS: RPF is very effectively treated by a combination of ureteric stents and steroids, with excellent long-term results using this approach. Continued follow-up is advised because of the possibility of recurrent disease. |
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Authors:
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Andrew C Fry; Sadmeet Singh; Smita S Gunda; Greg B Boustead; Damian C Hanbury; Thomas A McNicholas; Ken Farrington |
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Publication Detail:
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Type: Journal Article Date: 2008-03-07 |
Journal Detail:
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Title: Nephron. Clinical practice Volume: 108 ISSN: 1660-2110 ISO Abbreviation: Nephron Clin Pract Publication Date: 2008 |
Date Detail:
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Created Date: 2008-04-24 Completed Date: 2008-05-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101159763 Medline TA: Nephron Clin Pract Country: Switzerland |
Other Details:
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Languages: eng Pagination: c213-20 Citation Subset: IM |
Copyright Information:
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Copyright 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Nephrology, Lister Hospital, Stevenage, UK. andyfry@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Inflammatory Agents / therapeutic use Combined Modality Therapy Female Humans Male Middle Aged Retroperitoneal Fibrosis / complications, diagnosis, therapy* Retrospective Studies Steroids / therapeutic use* Treatment Outcome Ureter / surgery* Ureteral Obstruction / diagnosis, etiology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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